Study of Brain Microembolism After Closing Patent Foramen Ovale or Atrial Septal Defect Using Catheter Devices

What this Trial Is About

This research aims to study cerebral microembolization in patients undergoing transcatheter closure of patent foramen ovale PFO or atrial septal defect ASD. It also investigates the link between new cerebral microembolization and in situ blood clots within the PFO. PFO is common and linked to conditions like ischemic stroke, transient ischemic attack, migraines, and embolization, with clot formation possibly playing a role in related stroke or migraine cases. Participants will receive transcatheter closure using PFO or ASD occluder devices. Before closure, brain diffusion-weighted MRI DW-MRI scans will be done, with additional DW-MRI scans at 24 hours and one month after the procedure. During PFO closure, right atrial angiography and optical coherence tomography OCT will assess the PFO structure and detect any clots while the patient performs the Valsalva maneuver. Throughout the study, patients will undergo brain imaging before and after closure to monitor cerebral microembolization and thrombus presence. Researchers will measure new cerebral microembolization occurring from 24 hours to 4 weeks after closure. The study includes detailed imaging and clot evaluations to better understand microembolization risks and outcomes following PFO or ASD closure, with participation lasting through at least one month post-procedure.

Cerebral Microembolization Associated With PFO Closure