Actively Recruiting
Cerebral Oxygen Consumption Response to Increased Oxygen Supply and Postoperative Delirium in Older Surgical Patients
Led by Seoul National University Bundang Hospital · Updated on 2026-04-02
80
Participants Needed
1
Research Sites
111 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn whether the brain's ability to use oxygen during surgery is associated with postoperative delirium in adults aged 65 years and older undergoing general anesthesia. The main question it aims to answer is: \- Does reduced cerebral oxygen consumption responsiveness during surgery increase the risk of postoperative delirium in older patients? Participants who are undergoing elective laparoscopic surgery under general anesthesia as part of their routine medical care will have brain oxygen levels measured during surgery using a non-invasive forehead sensor, and will be assessed for delirium for up to three days after surgery.
CONDITIONS
Official Title
Cerebral Oxygen Consumption Response to Increased Oxygen Supply and Postoperative Delirium in Older Surgical Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing elective laparoscopic surgery under general anesthesia
- Age 65 years or older
You will not qualify if you...
- Diagnosis of dementia or presence of delirium before surgery
- Loss of capacity to provide informed consent
- Moderate or severe cerebrovascular stenosis diagnosed before surgery
- Moderate or severe obstructive or restrictive pulmonary dysfunction identified on preoperative pulmonary function testing
- Requirement for supplemental oxygen therapy before surgery
- History of neurological disorders (e.g., Parkinson's disease, stroke) or prior brain surgery
- Severe hepatic dysfunction (AST or ALT > 120 IU/L)
- Severe renal dysfunction (estimated GFR < 15 mL/min/1.73 m�b2)
- Persistent severe hemodynamic instability (mean arterial pressure < 60 mmHg)
- Skin conditions preventing placement of the forehead fNIRS sensor
- Combined surgical procedures performed concurrently
- Planned postoperative admission to the intensive care unit
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea, 13620
Actively Recruiting
Research Team
S
Soowon Lee, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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