Actively Recruiting
CEST in Low-grade Glioma Study
Led by Sunnybrook Health Sciences Centre · Updated on 2023-08-18
100
Participants Needed
2
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Low grade gliomas (LGGs) are malignant, infiltrative and incurable brain tumours that typically present in the younger population. This project proposes to use non-contrast metabolic "Saturation Transfer" (ST)-MRI to evaluate LGG tumour progression and aims to predict early changes in LGG. Early identification of LGG patients whose tumours will progress will permit early interventions. ST-MRI does not involve any intravenous injection of contrast and which acquires metabolic information not seen by standard MRI.
CONDITIONS
Official Title
CEST in Low-grade Glioma Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be at least 12 years of age
- Diagnosed with suspected low-grade glioma (oligodendroglioma or astrocytoma) before surgery or confirmed IDH1/2-mutant or IDH-wildtype low-grade glioma after surgery
- No contraindications to MRI
- Estimated glomerular filtration rate (eGFR) greater than 30 ml/min
- No prior chemotherapy or radiation therapy
- No need for upfront treatment such as surgery, chemotherapy, or radiation
- Followed at Sunnybrook Health Sciences Centre or St Michael's Hospital
You will not qualify if you...
- Require immediate post-surgical treatment with chemotherapy and/or radiation therapy
- Pregnant
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N3M5
Actively Recruiting
2
St. Michael's Hospital
Toronto, Ontario, Canada, M5B 1W8
Not Yet Recruiting
Research Team
M
Mary Jane Lim-Fat, MD
CONTACT
A
Arjun Sahgal, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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