Observational Study Using Saturation Transfer MRI to Monitor Low-grade Glioma Progression in Patients Aged 12 and Older

What this Trial Is About

Low grade gliomas LGGs are malignant, infiltrative brain tumors that are typically found in younger people and are currently incurable. This research is focused on using a special type of MRI called Saturation Transfer ST-MRI, which does not require contrast injection and captures metabolic information not visible on standard MRI. The goal is to evaluate tumor progression and predict early changes in LGG to allow for earlier interventions. Participants will have ST-MRI scans done during their routine imaging visits or within two weeks of their standard MRI scans. These ST-MRI scans include magnetization transfer and chemical exchange saturation transfer techniques and are used alongside standard care imaging without any additional treatment given as part of the study. During the study, researchers will track tumor changes using ST-MRI and compare these with standard MRI results to measure the time until tumor progression, defined by a change in volume or parameter over 10%. Participants will be followed for up to six years from their initial ST-MRI scan. The study involves regular imaging evaluations and monitoring to assess the accuracy of ST-MRI in detecting tumor progression.

CEST in Low-grade Glioma Study