Actively Recruiting
CEUS Evaluation of Hydrocephalus in Neonates and Infants
Led by Children's Hospital of Philadelphia · Updated on 2026-04-20
20
Participants Needed
1
Research Sites
64 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Hydrocephalus affects up to 2 out of every 500 births and results in long-term disability in up to 78% of those affected. The standard treatment of hydrocephalus is cerebrospinal fluid (CSF) diversion via placement of an invasive ventricular shunt to relieve elevated intracranial pressure (ICP). The clinical decision for CSF diversion is based on the ventricular size and clinical symptoms which are not robust indicators of brain health in neonatal hydrocephalus. The purpose of this study is to assess the safety and feasibility of performing brain contrast-enhanced ultrasound (CEUS) in neonates and infants with diagnosed and/or suspected hydrocephalus.
CONDITIONS
Official Title
CEUS Evaluation of Hydrocephalus in Neonates and Infants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females younger than 1.5 years old with diagnosed and/or suspected hydrocephalus
- Post menstrual age of 26 weeks or older
- Inpatients at the Children's Hospital of Philadelphia
- Parental or legally authorized representative permission
You will not qualify if you...
- History of hypersensitivity to Lumason
- Hemodynamic instability defined by rapid increase in cardiopulmonary support in past 12-24 hours
- Respiratory instability defined by rapid increase in respiratory support in past 12-24 hours (increased oxygen or nitric oxide)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
M
Misun Hwang, MD
CONTACT
M
Maria Mezher, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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