Actively Recruiting
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
Led by Adela, Inc · Updated on 2026-01-20
7000
Participants Needed
17
Research Sites
251 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers included in this study are brain, breast, bladder, cervical, colorectal, endometrial, esophageal, gastric, head and neck, hepatobiliary, leukemia, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, renal, sarcoma, and thyroid. These cancers were selected based on their prevalence and mortality to maximize impact on clinical care. Additionally, the ability of the whole-genome methylome enrichment platform to detect minimal residual disease after completion of cancer treatment and to detect relapse prior to clinical presentation will be evaluated in lung cancer. This cancer was selected based on the existing clinical landscape and treatment availability.
CONDITIONS
Official Title
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Newly diagnosed (within 120 days) with cancer or a recurrence of a cancer diagnosed more than 5 years ago of one of the following types: invasive brain, breast, bladder, cervical, colorectal, endometrial, esophageal, gastric, head and neck, hepatobiliary, lung, ovarian, pancreatic, prostate, renal, sarcoma, thyroid, leukemia, lymphoma, or multiple myeloma
- Able and willing to provide informed consent
- 40 years of age or older
- Not diagnosed with any cancer in the last 5 years for control participants (non-invasive cancer is allowed)
You will not qualify if you...
- Currently receiving any treatment for cancer
- Currently taking any demethylating agents or DNA hypomethylating agents
- Diagnosed with two or more invasive cancers at the same time
- Diagnosed with any invasive or non-invasive cancer besides the main cancer in the last 5 years
- Currently diagnosed with any chronic hematopoietic cancer in addition to the main cancer
- Currently diagnosed with any myelodysplastic syndromes or precursor hematologic conditions in addition to the main cancer
- Women known to be pregnant (self-reported)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 17 locations
1
City of Hope
Duarte, California, United States, 91010
Actively Recruiting
2
Miami Cancer Institute
Miami, Florida, United States, 33176
Actively Recruiting
3
North Georgia Health System
Gainesville, Georgia, United States, 306501
Actively Recruiting
4
Baptist Floyd
New Albany, Indiana, United States, 47150
Actively Recruiting
5
Baptist Corbin
Corbin, Kentucky, United States, 40701
Actively Recruiting
6
Baptist Hardin
Elizabethtown, Kentucky, United States, 42701
Actively Recruiting
7
Baptist Lexington
Lexington, Kentucky, United States, 40503
Actively Recruiting
8
Baptist Paducah
Paducah, Kentucky, United States, 42003
Withdrawn
9
Allina Health Cancer Institute
Minneapolis, Minnesota, United States, 55407
Actively Recruiting
10
Mayo Clinic
Rochester, Minnesota, United States, 55902
Actively Recruiting
11
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
12
Oregon Health Sciences University
Portland, Oregon, United States, 97201
Actively Recruiting
13
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
14
McLeod Health
Florence, South Carolina, United States, 29502
Actively Recruiting
15
Baptist (BHMCC)
Memphis, Tennessee, United States, 38120
Actively Recruiting
16
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States, 37203
Actively Recruiting
17
Elligo Health Research, Inc.
Austin, Texas, United States, 78704
Actively Recruiting
Research Team
B
Brian Allen, MS
CONTACT
M
Michelle Anderson
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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