Actively Recruiting
CGM and Lifestyle Changes in Patients With Impaired Glucose Tolerance
Led by Nemours Children's Clinic · Updated on 2025-11-26
15
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The incidence of type 2 diabetes (T2D) in children is increasing, paralleling the rising incidence of obesity. Preventing children and adolescents from developing T2D is critical. The health benefits of lifestyle modifications are well documented in this population, but success rates are low. Obesity in children and adolescents increases the risk of not only T2D but other complications as well, such as hypertension, dyslipidemias and more. The investigators hypothesize that having real-time glucose data with the use of a continuous glucose monitor (CGM) in obese patients with impaired glucose tolerance will improve adherence to lifestyle modifications. As a result, a decrease in body mass index (BMI) is expected with subsequent improvement in insulin sensitivity, thus reducing risk of obesity-related complications later in childhood/adolescence and adulthood.
CONDITIONS
Official Title
CGM and Lifestyle Changes in Patients With Impaired Glucose Tolerance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children 10 to under 18 years old
- Impaired glucose tolerance based on standardized oral glucose tolerance test or fasting glucose per American Diabetes Association criteria
- Overweight or obese with BMI at or above the 85th percentile for age and sex
- Pubertal patients defined as females with breast Tanner stage II or above, or males with testicular volume 4 mL or more
You will not qualify if you...
- Existing diagnosis of type 1 or type 2 diabetes
- Prepubertal patients
- Taking medications affecting insulin sensitivity (e.g., chronic corticosteroids), except stable dose of metformin
- Patients or families unwilling or unable to wear the CGM device consistently during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Nemours Children's Clinic
Jacksonville, Florida, United States, 32207
Actively Recruiting
Research Team
L
Larry Fox, MD
CONTACT
L
Liezel Riego
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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