Actively Recruiting
Change in Serum Biomarkers After Endovascular Treatment for Acute Anterior Circulation Large Vessel Occlusion
Led by General Hospital of Shenyang Military Region · Updated on 2025-08-21
200
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Acute ischaemic stroke (AIS) results in high rates of neurological morbidity and mortality, especially in patients with large vessel occlusion (LVO). Endovascular therapy (EVT) has been approved as the most effective treatment for patients with LVO , but about half patients undergoing EVT did not achieve good outcome. The mechanisms of poor prognosis are complex. How to accurately identify serological biomarkers related to patients' clinical prognosis is an important research topic nowadays.
CONDITIONS
Official Title
Change in Serum Biomarkers After Endovascular Treatment for Acute Anterior Circulation Large Vessel Occlusion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years
- Diagnosis of acute anterior circulation large vessel occlusion within 24 hours of symptom onset
- Planned to receive endovascular treatment
- Pre-stroke modified Rankin Scale (mRS) score of 0 to 1
- Baseline National Institutes of Health Stroke Scale (NIHSS) score of 6 or higher
- Signed informed consent
You will not qualify if you...
- Contraindications to internal jugular vein cannulation
- Received intravenous thrombolysis
- Hemorrhagic stroke (cerebral hemorrhage or subarachnoid hemorrhage)
- Coagulation disorders, systemic bleeding tendency, or thrombocytopenia (platelet count less than 100×10⁹/L)
- Severe heart, liver, or kidney failure (elevated ALT or AST more than twice normal, elevated serum creatinine more than 1.5 times normal, or need for dialysis) or other serious medical conditions
- Severe uncontrolled high blood pressure (systolic > 200 mmHg or diastolic > 110 mmHg)
- Pregnant or lactating women
- Other conditions deemed unsuitable for the trial by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
General Hospital of Northern Theater Command
Shenyang, China, 110840
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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