Pilot Study on How Proton Pump Inhibitors Affect Esophagus Flexibility in Adults with Esophageal Eosinophilia

What this Trial Is About

Researchers are investigating whether treating eosinophilic inflammation in the esophagus improves how well the esophagus can stretch, known as esophageal distensibility. This pilot study focuses on patients with eosinophilic esophagitis EoE, a condition where eosinophils affect the upper, middle, and lower parts of the esophagus. The study aims to measure esophageal distensibility both near the top proximal and bottom distal before and after treatment, as previous measurements focused only on the lower esophagus and esophagogastric junction. Participants will receive a two-month course of high-dose proton pump inhibitors PPIs to reduce eosinophilia in their esophagus. The study uses a diagnostic tool called EndoFlip to assess esophageal distensibility. The main intervention is PPI treatment, and the research team will measure changes in esophageal distensibility and eosinophil counts before and after the treatment period. During the study, patients will undergo biopsies from the upper, middle, and distal esophagus to confirm eosinophilia and monitor changes. The primary outcome is the change in esophageal distensibility after two months of treatment, and a secondary outcome is the change in eosinophil numbers. The study includes adults aged 18 to 65 years and excludes certain conditions or histories that could affect results. The total treatment and observation period is two months.

Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study