Actively Recruiting
Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study
Led by Indiana University · Updated on 2025-11-24
10
Participants Needed
2
Research Sites
530 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This pilot study will explore whether treatment of eosinophilic inflammation in the esophagus is associated with an improved distensibility of the esophagus. Furthermore, previous studies of the esophagus using EndoFlip only measured distensibility of the distal esophagus, specifically the distal esophagus and esophagogastric junction. Eosinophilia in EoE has been demonstrated to affect both upper, middle and lower esophagus. The aim is to measure distensibility both proximal and distal, before and after treatment.
CONDITIONS
Official Title
Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of eosinophilia on esophageal biopsy, defined as a peak count of > 15 eosinophils per high power field (HPF) on light microscopy based on biopsies from at least 2 of the 3 biopsy segments (upper, middle and distal esophagus)
You will not qualify if you...
- Secondary causes of esophageal eosinophilia have been excluded, such as eosinophilic GI diseases, celiac disease, Crohn's disease, esophageal infection, hypereosinophilic syndrome, drug hypersensitivity, vasculitis, pemphigus, connective tissue diseases, graft vs. host disease
- Age < 18 or > 65 years
- Contraindication for biopsy, such as presence of esophageal varices, coagulopathy
- History of esophageal surgery, gastric or esophageal malignancy, anatomical abnormality, or major primary motility disorder (such as achalasia)
- Pregnancy
- Prisoners
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Indiana University Health University Hospital
Indianapolis, Indiana, United States, 46202
Actively Recruiting
2
Indiana University
Indianapolis, Indiana, United States, 46202
Actively Recruiting
Research Team
M
Maureen Schilling
CONTACT
L
Lainna Cohen
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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