Study of Glucose Changes Around Liver Transplant in Adults with Cirrhosis Tracking Diabetes Risk Using Glucose Monitors and Other Tests

What this Trial Is About

This research aims to identify risk factors for developing diabetes after liver transplant in adults with cirrhosis who do not have diabetes at the time of evaluation. The study explores whether tests such as laboratory work, body measurements, functional tests, imaging, wrist activity monitoring, continuous glucose monitoring, and oral glucose tolerance testing can predict post-transplant diabetes. The University of Chicago is leading this observational study to improve understanding of diabetes risk in this population. Participants will receive devices including a continuous glucose monitor, wrist actigraph, and home sleep apnea testing device, along with questionnaires about demographics, sleep, and physical activity. They will undergo a two-hour oral glucose tolerance test with frequent sampling and body composition analysis using bio-electrical impedance. These tests, except the sleep apnea test, will be repeated every three months before and through the transplant. After transplant, testing resumes at three months or one month after steroid doses are minimized. One year post-transplant, glucose monitoring and oral glucose tolerance testing stop, but medical follow-up continues electronically for up to five years. During the study, participants will be monitored regularly with various tests and questionnaires to assess glucose tolerance and insulin secretion. Researchers will track early post-transplant high blood sugar and diabetes development up to one year after transplant. Long-term health outcomes will be followed electronically up to five years after the transplant. The study involves multiple visits, device usage, and tests to gather detailed information about changes in glucose tolerance throughout the transplant process.

Changes in Glucose Tolerance in Patients With Cirrhosis Peri-Liver Transplant