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Effect of Preventive Oxytocin on Bleeding During Second Trimester Dilation and Evacuation in Clinic
Led by University of Colorado, Denver · Updated on 2024-12-10
150
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the effect of prophylactic oxytocin on bleeding rates during second trimester dilation and evacuation D&E procedures performed in the clinic. This Phase 2 randomized study aims to compare hemorrhage rates and blood loss between groups receiving oxytocin versus placebo, helping to determine if oxytocin can reduce bleeding complications during these procedures. Participants are randomly assigned to receive either 40 units of intravenous oxytocin mixed in 1000 mL of normal saline or 1000 mL of normal saline alone at the time of tenaculum placement for the D&E procedure. The study is triple-blinded and compares these two interventions during the operation. During the procedure day, researchers measure hemorrhage and quantitative blood loss as primary outcomes. Secondary outcomes include procedure time. Participants are monitored throughout the clinic visit, and data on bleeding and procedure duration are collected. The total participation period covers the day of the procedure, with safety and bleeding outcomes evaluated immediately during and after the D&E.
CONDITIONS
Brief Title
Changes in Hemorrhage With Prophylactic Oxytocin for Dilation and Evacuation
Research Team
M
Megan Masten, MD
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