Study of Oral Microbiome Changes from Having Teeth to Tooth Loss and After Dental Implant Placement in Adults with Severe Periodontitis

What this Trial Is About

Researchers are examining how the oral microbiome changes during the transition from having some natural teeth partial dentition to being fully edentulous no remaining teeth and after dental implant placement in people with severe periodontitis. The study aims to understand how different implant materials and surfaces might affect these microbiome changes and to gather data for future long-term studies. This research focuses on patients with terminal dentition due to periodontitis who plan to replace their teeth with implant-supported restorations. Participants will undergo several study visits starting with screening and full mouth examination, followed by baseline microbial sampling and tooth extractions. After 3 to 4 months, they will have diagnostic visits including imaging and denture adjustments before implant placement. Two types of implants, Intra-Lock Fusion Implants or Tapered Pro Implants, will be randomly assigned to each participant. Implant placement involves a two-stage healing process, with follow-up visits for suture removal, implant uncovering, and restorative connection. Microbial samples and clinical measurements will be collected at multiple stages including before extractions, implant placement, restorative connection, and at 6 and 12 months after loading. Throughout the study, participants will provide microbial samples from the oral mucosa, tongue, and peri-implant areas to investigate microbiome shifts. Clinical assessments include probing depth, keratinized mucosa, bleeding on probing, and standardized X-rays of the implants. Only microbial sampling is performed for research other procedures are part of standard dental care. The study tracks oral microbiome composition changes over an average of 24 months to evaluate differences based on dentition status and implant types.

Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement