Actively Recruiting
Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement
Led by Case Western Reserve University · Updated on 2025-06-04
12
Participants Needed
1
Research Sites
193 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in subjects affected by severe periodontitis; to evaluate if microbiome changes in relation to the used of different implant material/surface; and to assess the variance of the changes to determine the sample size for future longitudinal prospective studies.
CONDITIONS
Official Title
Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 21 years of age
- Diagnosis of Stage III or IV periodontitis based on full mouth probing and full mouth x-rays
- Planned for full mouth extraction and replacement by dental implants
- Rehabilitation with implant-supported restorations in the upper jaw and/or lower jaw
- At least 2 implants available for examination
- No bone augmentation required
You will not qualify if you...
- Conditions requiring chronic routine prophylactic use of antibiotics
- Conditions requiring prolonged use of steroids
- History of leukocyte dysfunction and deficiencies
- Bleeding disorders
- History of neoplastic disease requiring radiation or chemotherapy
- Metabolic bone disorders
- Uncontrolled endocrine disorder
- Use of any investigational drug or device within 30 days prior to implant surgery
- Alcoholism or drug abuse
- Infection with HIV
- Conditions or circumstances preventing study completion or interfering with results, such as non-compliance or unreliability
- Local inflammation
- Mucosal diseases such as erosive lichen planus
- History of local irradiation therapy
- Osseous lesion
- Active infection with pus or fistula
- Persistent intraoral infection other than periodontitis
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Case Western Reserve University Department of Periodontics
Cleveland, Ohio, United States, 44106
Actively Recruiting
Research Team
G
Gian Pietro Schincaglia, DDS,PhD
CONTACT
E
Elysha Pomerantz, DMD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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