Actively Recruiting

Age: 18Years +
All Genders
Healthy Volunteers
ID03240965

Changes in Sensitivity of Swallowing-relevant Structures, Taste and Smell in Stroke Patients

Led by University of Giessen · Updated on 2023-12-01

200

Participants Needed

1

Research Sites

95 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are investigating changes in swallowing, taste, and smell in patients who have had a stroke. This study focuses on how stroke affects swallowing by measuring sensitivity in swallowing-related areas and assessing neuropsychological issues like swallowing apraxia. The research also compares results with younger and older healthy volunteers to better understand these changes after stroke. The study involves diagnostic tests including flexible endoscopic evaluation of swallowing (FEES) for stroke patients, measuring sensitivity thresholds with a pudendal electrode, taste and smell tests, and neuropsychological assessments for cognitive issues related to swallowing. Control groups consist of younger and older volunteers who can consent to participate. Participants will undergo assessments within 96 hours after their initial stroke symptoms, including swallowing function, neuropsychological deficits, lesion site imaging, sensitivity, and taste/smell testing. Healthy volunteers provide baseline comparison data. The study is observational and aims to better understand swallowing difficulties and sensory changes in stroke patients. Participation includes diagnostic tests and cognitive assessments conducted shortly after stroke onset.

CONDITIONS

Brief Title

Changes in Sensitivity, Taste and Smell in Stroke Patients

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Volunteers must provide informed consent
  • Stroke patients must provide informed consent
  • Stroke patients must have a new supratentorial stroke less than 72 hours old confirmed by CT or MRI
Not Eligible

You will not qualify if you...

  • History of prior stroke or swallowing difficulties
  • Extensive white matter lesions seen in CT or MRI scans
  • Allergies to odorous substances or flavoring
  • Contraindications for flexible endoscopic evaluation of swallowing (FEES), CT, or MRI in stroke patients

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - Up to 72 hours from stroke onset for stroke patients

Participants are screened for eligibility to participate in the trial.

1 visit (in-person) for eligibility confirmation and consent

Diagnostic Evaluation

Duration - Within 96 hours after initial symptoms

Participants undergo tests to assess swallowing sensitivity, taste, smell, and neuropsychological function.

1 to 2 visits depending on participant group and assessments

Long-term Monitoring

Duration - Up to 96 hours after initial symptoms

Participants are observed for changes in dysphagia and neuropsychological deficits after initial assessments.

Follow-up visits as scheduled within 4 days

Trial Site Locations

Total: 1 location

1

Universitätsklinikum Gießen

Giessen, Hesse, Germany, 35392

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Research Team

T

Tobias Braun, M.D.

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

3

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