Actively Recruiting
Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure
Led by Tufts Medical Center · Updated on 2025-04-23
60
Participants Needed
1
Research Sites
149 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to determine, via skeletal muscle ultrasound (US), the extent, timing and relationship between skeletal muscle mass loss and outcomes after orthotropic heart transplantation (OHT) and left ventricular assist device (LVAD) implantation amongst patients with cardiogenic shock. Advanced therapies such as OHT and VADs in the heart failure (HF) population may promote skeletal muscle mass and subsequent quality of life, but there is a lack of literature assessing muscle mass changes in HF patients before and after advanced therapies using US imaging. Therefore this observational study will provide further insight into the 1) changes in lean body mass during critical illness and 2) the feasibility of using bedside US to assess lean body mass in the inpatient setting.
CONDITIONS
Official Title
Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Over 18 years of age
- Ejection fraction less than 40%
- Cardiogenic shock defined by clinical criteria including any of: lactate over 2.5 mmol/L, systolic blood pressure under 90 mmHg, acute kidney or liver injury, or cardiac index under 2.1 on hemodynamic monitoring
- Clinical requirement for at least one pressor, inotrope, or temporary mechanical circulatory support device
You will not qualify if you...
- History of LVAD or other durable ventricular assist device
- Clinical disorders causing skeletal muscle weakness or wasting such as muscular dystrophy, mitochondrial disorder, active cancer, or modified Rankin score 4 or higher after stroke
- Patients receiving chronic enteric or parenteral nutrition support
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tufts Medical Center
Boston, Massachusetts, United States, 02111
Actively Recruiting
Research Team
A
Amanda R Vest, MBBS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here