New Approaches in Prognostic Assessment and Personalized Treatment of Classical Hodgkin Lymphoma Using Genetic Profiling, Liquid Biopsy, and Imaging Biomarkers

What this Trial Is About

Researchers are studying Classical Hodgkins Lymphoma cHL, a rare cancer of the immune system mostly affecting young adults. Despite advances in treatment, many patients experience relapse or resistant disease. The study aims to better understand the genetic and biological complexity of cHL using molecular profiling and advanced imaging techniques, to identify new markers that predict disease progression and improve personalized treatments. The study includes three groups patients who have completed treatment and entered follow-up, patients with confirmed relapse or disease progression, and a retrospective group of previously treated patients from medical archives. It combines genetic analysis, gene expression profiling, liquid biopsy of circulating DNA, and radiomic analysis of PET scans to capture tumor characteristics at diagnosis and during disease progression. Participants will provide tissue and blood samples, and undergo PET scan evaluations. Researchers will analyze genetic mutations, compare findings from tissue and liquid biopsies, and correlate these data with patient outcomes. The study will track participants over several years to assess how genetic and imaging markers relate to disease control, aiming to improve risk assessment and treatment decisions in cHL.

Changing Paragidms In The Prognostic Assessment Of Hodgkin Lymphoma