Study of Clonal Haematopoiesis in Adults 55 and Older with Monitoring and Support at a Dedicated Clinic

What this Trial Is About

This research focuses on people aged 55 and older who have or may have clonal haematopoiesis CH, a condition where a group of blood-forming stem cells with specific mutations grows abnormally. CH is common in older adults and can increase the risk of serious health issues like blood cancers, heart disease, and strokes. The study aims to better understand CH detection, outcomes, and patient experiences, helping to guide future care and research in Australia. Participants confirmed or suspected to have CH will be invited to a specialized clinic for molecular testing and monitoring. The study will establish a registry to track their health over time, with regular visits scheduled for assessments. These visits will include blood tests and evaluations to monitor for complications, quality of life, psychological well-being, and disease progression. The study also offers personalized support to participants based on their condition. During the study, participants will provide blood samples and health information at multiple visits over five years, starting with screening and continuing with follow-ups at weeks 6, 52, 104, 156, 208, and 260. Researchers will assess changes in blood cell markers, psychological distress, and participants understanding of CH. The study will create a detailed database to help doctors improve CH care and support future research efforts.

CHAPTER: Clonal Haematopoiesis Assessment: Prevention, Treatment and Research