Actively Recruiting
Characterisation of Endothelial Cells in Different Inflammatory Pathologies
Led by Royal Surrey County Hospital NHS Foundation Trust · Updated on 2024-09-25
105
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
Sponsors
R
Royal Surrey County Hospital NHS Foundation Trust
Lead Sponsor
U
University of Surrey
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to characterise changes in gene expression in endothelial cells in patients with either sepsis or post major abdominal surgery. The main question we plan to answer is: 'What molecular pathways are differentially expressed during inflammatory pathologies?'
CONDITIONS
Official Title
Characterisation of Endothelial Cells in Different Inflammatory Pathologies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older
- Able and willing to give consent
- Healthy volunteers
- Patients admitted to RSFT for planned major surgery
- Emergency ICU admission at RSFT with sepsis meeting sepsis 3.0 definition
You will not qualify if you...
- Healthy volunteers must not be current hospital patients
- No inflammatory diseases including arthritis, peripheral artery disease, vasculitis, diabetes, cardiovascular disease, or chronic kidney disease
- Not on immunomodulatory medications such as corticosteroids
- No recent major trauma or surgery requiring hospitalization within last 2 months
- Surgical patients with restricted liberty, prisoners or under legal protection
- Anticipated difficult venous cannulation
- Surgical patients with inflammatory diseases or on immunosuppressants
- Received chemotherapy within 2 weeks of sampling
- Receiving vasopressor support before surgery
- Critically ill patients with restricted liberty, prisoners or under legal protection
- Anticipated difficult venous cannulation
- Critically ill patients with inflammatory diseases or on immunosuppressants
- Received chemotherapy within 2 weeks of sampling
- Recent major trauma within last 2 months
AI-Screening
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Trial Site Locations
Total: 1 location
1
Royal Surrey NHS Foundation Trust
Guildford, Surrey, United Kingdom, GU27XX
Actively Recruiting
Research Team
B
Ben Creagh-Brown, BM, PhD
CONTACT
C
Charlie Piercy, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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