Study of Intestinal Microbiota in Adults With Spondyloarthritis or Rheumatoid Arthritis Compared to Healthy Adults

What this Trial Is About

Researchers are investigating the differences in intestinal microbiota between patients with spondyloarthritis SPA or rheumatoid arthritis RA and healthy volunteers. The study aims to compare the biodiversity of gut bacteria by DNA sequencing to identify specific bacterial markers associated with each disease. Additionally, the study explores how clinical factors like age, gender, disease duration, and ongoing treatments relate to the gut microbiota composition and the connection between faecal and plasma metabolomes and intestinal bacteria. Participants include groups of 100 SPA patients, 100 RA patients, and 200 healthy control subjects. Biological samples of feces and blood are collected at the beginning of the study to analyze the microbiota. This observational research is conducted at the rheumatology department of Ambroise Par hospital in France, focusing on gathering detailed data without administering treatments. Throughout the study, participants provide samples for bacterial and microbiota composition analysis, which are assessed up to four years after enrollment. Researchers monitor the gut bacteria profiles and their relation to clinical parameters over time. The study includes both patients and healthy adults, with evaluations centered on understanding microbiota differences and identifying potential biomarkers for SPA and RA.

Characterisation of Intestinal Microbiota of Patients With Spondyloarthritis or Rheumatoid Arthritis