Study of Adult Patients with Hypophosphatasia in Rheumatology to Identify Diagnosis Patterns and Develop a Diagnostic Algorithm

What this Trial Is About

Researchers are conducting a non-interventional, prospective, multi-center study to explore the occurrence of hypophosphatasia HPP among adult patients who visit rheumatology departments. The study aims to better understand the characteristics of HPP in this population and to develop a diagnostic algorithm to help identify the condition. This investigation involves collecting and analyzing data without altering patient care. Participants will undergo diagnostic tests, including a second alkaline phosphatase ALP measurement taken 1 to 4 weeks after the initial test. Patients are grouped based on whether they have persistent low ALP levels indicating HPP or transient low ALP levels as a control group without HPP. This approach helps researchers assess the prevalence and patterns of HPP in rheumatology patients. During the study, participants will provide informed consent and be monitored over a 36-month period to determine the prevalence of HPP. The study involves routine clinical assessments and laboratory tests, focusing on ALP levels. Data collected will assist in establishing an algorithm to improve diagnosis of HPP in adults. The study started in August 2024 and is expected to continue until September 2027.

Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study