Actively Recruiting
Characteristics of Immunity in Gut Mucosa, Spinal Fluid, Lymph Node and Blood of HIV Negative Thais and Thais With HIV Infection
Led by SEARCH Research Foundation · Updated on 2026-04-27
232
Participants Needed
1
Research Sites
1022 weeks
Total Duration
On this page
Sponsors
S
SEARCH Research Foundation
Lead Sponsor
A
Armed Forces Research Institute of Medical Sciences, Thailand
Collaborating Sponsor
AI-Summary
What this Trial Is About
To compare the immunophenotyping and immunochemistry in the gut mucosa of HIV negative and non-acute HIV-infected adults 1. To compare the immunophenotyping of the gut mucosa to that of the peripheral blood in HIV negative and in non-acute HIV-infected subjects 2. To compare the immunophenotyping of the peripheral blood in HIV negative and non-acute HIV-infected adults to the findings from acutely HIV-infected subjects in the WRAIR#1494/RV254/ SEARCH 010 study 3. To compare immunologic markers in the genital compartment compared to the peripheral blood in HIV negative and non-acute HIV-infected adults to the findings from acutely HIV-infected subjects in the WRAIR#1494/RV254/ SEARCH 010 study 4. Archive samples for immunologic and virologic testing
CONDITIONS
Official Title
Characteristics of Immunity in Gut Mucosa, Spinal Fluid, Lymph Node and Blood of HIV Negative Thais and Thais With HIV Infection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 50 years old
- HIV negative subjects must have negative results by 4th generation EIA and NAT (Aptima)
- HIV positive subjects must have a positive 4th generation EIA and a positive less sensitive EIA
- Understand the study and sign informed consent form; if unable to read, consent can be given by thumb print with staff assistance
You will not qualify if you...
- Have gastrointestinal disorders or symptoms requiring endoscopy or systemic autoimmune diseases that could affect colon mucosa
- Active AIDS-defining opportunistic infection within 30 days prior to entry for HIV-positive subjects; must be off acute treatments for at least 14 days
- Platelet count below 150,000/ml or abnormal clotting tests (PT, PTT, INR)
- Have a self-reported bleeding disorder
- Untreated syphilis infection
- Abnormal neurological exam suggesting central nervous system issues if planning lumbar puncture
- Positive urine pregnancy test
- Medical or psychiatric conditions that interfere with study adherence or informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
SEARCH Research Foundation
Bangkok, Bangkok, Thailand, 10330
Actively Recruiting
Research Team
N
Nitiya Chomchey, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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