Actively Recruiting
The Characteristics of Oral Microbiota in Chronic Pancreatitis and Autoimmune Pancreatitis
Led by Ruijin Hospital · Updated on 2025-06-11
360
Participants Needed
1
Research Sites
53 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
There are more than 700 different bacteria colonized in human oral cavity, which are collectively referred to as oral microbiota. Emerging evidence suggests that oral microbiota plays a series of important roles in human health, such as immune response, carcinogen metabolism and nutrient digestion. The changes of oral microbiota composition are closely related to the occurrence and development of pancreatic diseases. Previous studies have found that there are dense bacterial biofilms in the pancreatic duct of patients with calcified pancreatitis, including oral bacterial types. However, most studies only focused on the changes of gut microbiota in patients with chronic pancreatitis, and there were lack of research and description on the changes of oral microbiota in patients with chronic pancreatitis. In this study, we will extract and sequence bacterie's full-length 16S rRNA to describe the characteristics of oral microbiota in patients with chronic pancreatitis, confirming that there are changes in oral microbiota in patients with chronic pancreatitis, and compare the differences of oral microbiota in patients with chronic pancreatitis, pancreatic cancer and autoimmune pancreatitis.
CONDITIONS
Official Title
The Characteristics of Oral Microbiota in Chronic Pancreatitis and Autoimmune Pancreatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent form and willingness to complete sample collection
You will not qualify if you...
- Previous digestive system surgery
- Currently pregnant or breastfeeding
- Having infectious diseases, malignant tumors, or other digestive system diseases such as inflammatory bowel disease, irritable bowel syndrome, abdominal diseases, or gastroesophageal reflux
- Use of antibiotics or immunosuppressive drugs within 30 days before sampling
- Daily use of probiotics
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Gastroenterolog, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai, China, China
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here