Actively Recruiting
Characteristics of Papez Loop Neural Network in T2DM （Type 2 Diabetes Mellitus）
Led by Nanjing First Hospital, Nanjing Medical University · Updated on 2025-04-04
400
Participants Needed
1
Research Sites
347 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a cross-sectional and longitudinal study to investigate the characteristic changes in Papez's circuit neural network activity and connectivity based on multimodal MRI, and through follow-up study of the interaction between the internal brain regions of Papez circuit and the function of the external neural network, a prediction model of the characteristic changes of Papez circuit neural network was constructed based on machine learning technology.
CONDITIONS
Official Title
Characteristics of Papez Loop Neural Network in T2DM （Type 2 Diabetes Mellitus）
Who Can Participate
Eligibility Criteria
You may qualify if you...
- T2DM patients meeting WHO 1999 diabetes diagnostic criteria with 3-20 years duration or healthy controls with fasting blood glucose < 6.1 mmol/l and glycosylated hemoglobin < 5.7%
- Right-handed individuals aged 45 to 70 years with at least 8 years of education
- No contraindications to MRI scanning such as electronic or metal implants
- Visual and hearing abilities sufficient to complete evaluations
- No history of substance abuse or dependence; not currently using sedative or antidepressant medications; no long-term use of cognitive-enhancing drugs
You will not qualify if you...
- Acute metabolic complications or history of severe hypoglycemia
- Severe diseases of heart, liver, lung, kidney, or blood systems
- Hyperthyroidism or hypothyroidism
- History of stroke, Alzheimer's disease, epilepsy, Parkinson's disease, or other neurological disorders
- History of mental illness such as depression, mania, or alcohol dependence
- History of loss of consciousness due to neurological diseases or traumatic brain injury
- Surgical trauma or infection within one month before laboratory examination
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University
Nanjing, Jiangsu, China, 210000
Actively Recruiting
Research Team
W
Wenqing Xia, PHD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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