Actively Recruiting
Characteristics of Persistent Pain Composition Following Total Hip or Knee Arthroplasty: a Descriptive Study
Led by Rigshospitalet, Denmark · Updated on 2026-04-01
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
R
Rigshospitalet, Denmark
Lead Sponsor
B
Bispebjerg Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the types of persistent pain experienced by patients after total hip or knee arthroplasty, including total knee arthroplasty (TKA), total hip arthroplasty (THA), and unicompartmental knee arthroplasty (UKA). Despite high success rates of these surgeries, up to 20% of patients report moderate to severe pain that continues beyond normal healing. The study aims to identify the prevalence of different types of pain, such as neuropathic, nociplastic, and nociceptive pain, to better understand and improve pain management before and after surgery. This observational study will re-invite about 100 patients with persistent postoperative pain from an initial group of approximately 7,000 respondents who consented to further contact. Participants will complete standardized questionnaires assessing neuropathic pain (DN4), nociplastic pain (IASP criteria and Fibromyalgia Survey Questionnaire), and nociceptive pain (KOOS/HOOS pain domains). The study will compare current pain assessments with previous baseline results and explore differences between patients with and without neuropathic pain. Participants will provide detailed responses through questionnaires regarding their pain experience, satisfaction with surgery outcomes, and considerations for potential re-operation. Researchers will analyze the prevalence of nociplastic pain and the proportion of patients experiencing significant pain in multiple categories. Follow-up assessments will occur one year after surgery to evaluate changes in pain scores using validated tools. The findings aim to guide targeted pain management strategies for patients undergoing hip or knee arthroplasty.
CONDITIONS
Brief Title
Characteristics of Persistent Pain Composition Following Total Hip or Knee Arthroplasty: a Descriptive Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults with persistent moderate to severe pain (NRS above 3) after total hip arthroplasty (THA), total knee arthroplasty (TKA), or unicompartmental knee arthroplasty (UKA)
- Acceptance to be contacted for study participation
You will not qualify if you...
- Having undergone re-operation after arthroplasty
- Having joint dislocation (luxation)
- Not willing to be contacted for the study
- Experiencing post-operative complications such as prosthesis infection, thromboembolism, or prosthesis fracture
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote) for eligibility confirmation and consent
Duration - Up to 1 year
Participants with persistent moderate to severe pain after hip or knee arthroplasty complete questionnaires to assess different types of pain and their pain experience.
Participants complete questionnaires at baseline and at 1 year
Trial Site Locations
Total: 1 location
1
Rigshospitalet
Østerbro, København Ø, Denmark, 2100
Actively Recruiting
Research Team
M
Milan Mohammad, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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