Actively Recruiting
Pathophysiological Characterization of Chronic Hand Eczema Subtypes and Atopic Dermatitis Using Noninvasive Molecular and Imaging Techniques in Adults With Moderate to Severe Disease and Healthy Volunteers
Led by Dr. Robert Bissonnette · Updated on 2026-04-09
270
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating chronic hand eczema (CHE) and atopic dermatitis (AD) in adults with moderate to severe forms of these conditions, as well as in healthy volunteers. The study aims to characterize differences in skin features and molecular markers over time using noninvasive methods. It also evaluates how disease severity relates to lifestyle, occupation, smoking, and quality of life. Participants include adults with moderate to severe CHE, those with moderate to severe AD, and healthy adults. The study uses noninvasive imaging and molecular techniques to assess skin changes and collects samples such as plasma, serum, blood, stool, and skin materials for long-term analysis. An optional genetic analysis called tape stripping may be performed on CHE participants. During the 12-month study, participants undergo assessments of skin morphology and molecular signatures, alongside evaluations of quality of life and disease impact. Samples are stored for up to 10 years to support further research. Participants are monitored for changes in skin condition and lifestyle effects, with data compared across the groups including healthy controls.
CONDITIONS
Brief Title
Characterization of Chronic Hand Eczema
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 to 65 years at the time of consent
- Willing and able to provide informed consent
- Able to comply with all study procedures and available for entire study duration
- For CHE subjects: history of moderate to severe chronic hand eczema for at least 6 months with defined severity and subtypes
- For AD subjects: clinically confirmed moderate to severe atopic dermatitis with at least 6 months history and no recent significant flares
- For healthy volunteers: good general health based on medical history and physical exam
You will not qualify if you...
- Skin diseases or conditions interfering with study assessments
- Use of systemic antibiotics within 2 weeks prior to Day 1
- Use of topical antibiotics or products containing urea or salicylic acid within 1 week prior to Day 1
- Receipt of biological agents within 12 weeks or 5 half-lives prior to Day 1
- Use of investigational products or devices within 4 weeks prior to Day 1
- Recent excessive sun exposure, tanning, or planned sun trips within 4 weeks prior to Day 1
- Pregnancy or planning pregnancy during the study
- For CHE subjects: infected eczema, protein contact dermatitis, recent use of specific medications or treatments affecting eczema
- For AD subjects: infected AD, lesions on hands or feet, recent use of specific medications or treatments affecting AD
- For healthy volunteers: history of atopic dermatitis, allergic rhinitis, or asthma
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 12 months
Participants undergo non-invasive assessments to characterize skin morphological parameters and molecular signatures over time.
Duration - 10 years
Participants provide biological samples and data for biobanking to support future research.
Trial Site Locations
Total: 1 location
1
Innovaderm Research
Montreal, Quebec, Canada, H2X 2V1
Actively Recruiting
Research Team
A
Ana Palijan, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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