Study of Chronic Hand Eczema and Atopic Dermatitis Using Noninvasive Skin and Molecular Tests in Adults with Moderate to Severe Conditions and Healthy Volunteers

What this Trial Is About

Researchers are investigating chronic hand eczema CHE and atopic dermatitis AD in adults with moderate to severe forms of these conditions, as well as in healthy volunteers. The study aims to characterize differences in skin features and molecular markers over time using noninvasive methods. It also evaluates how disease severity relates to lifestyle, occupation, smoking, and quality of life. Participants include adults with moderate to severe CHE, those with moderate to severe AD, and healthy adults. The study uses noninvasive imaging and molecular techniques to assess skin changes and collects samples such as plasma, serum, blood, stool, and skin materials for long-term analysis. An optional genetic analysis called tape stripping may be performed on CHE participants. During the 12-month study, participants undergo assessments of skin morphology and molecular signatures, alongside evaluations of quality of life and disease impact. Samples are stored for up to 10 years to support further research. Participants are monitored for changes in skin condition and lifestyle effects, with data compared across the groups including healthy controls.

Characterization of Chronic Hand Eczema