Actively Recruiting
PRESTO - Characterization and Clinical Outcomes of Alopecia Areata Patients Treated With Ritlecitinib in a Real-world Cohort: A Multinational, Prospective Observational Study
Led by Pfizer · Updated on 2026-06-01
850
Participants Needed
58
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Alopecia areata (AA) is a chronic autoimmune condition causing nonscarring hair loss on the scalp and other body areas, affecting people of all ages, genders, and races. The main types include patchy alopecia, alopecia totalis, and alopecia universalis. Researchers aim to study the real-world effectiveness and patient outcomes of ritlecitinib, a drug approved for treating severe AA in patients 12 years and older, building on results from previous clinical trials. Participants in this observational study will receive ritlecitinib as prescribed by their doctors according to the approved label and standard care practices, independent of the study. The study will follow patients over time to observe treatment patterns, disease progression, and responses to ritlecitinib in routine clinical settings. Treatment dosing and schedules will be determined by physicians based on individual patient needs. Throughout the study, participants will attend regular clinic visits to assess disease severity, hair regrowth, and other clinical features using tools like the Severity of Alopecia Tool score. Patient-reported outcomes such as treatment satisfaction and quality of life will also be collected. Researchers will monitor changes over weeks 24, 48, 72, and 96 to evaluate effectiveness and safety. The study aims to capture comprehensive real-world data on ritlecitinib use in AA patients.
CONDITIONS
Brief Title
Characterization And Clinical Outcomes of AA Patients Treated With Ritlecitinib
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female patients aged over 12 years at baseline
- Diagnosed with alopecia areata confirmed by a certified dermatologist
- Prescribed ritlecitinib as per the product label independent of study enrollment
- Signed informed consent (and assent for adolescents as required) obtained
- Willing and able to comply with regular clinic visits and complete patient questionnaires
You will not qualify if you...
- Diagnosed with other types of alopecia or hair loss diseases (e.g., androgenetic alopecia, traction alopecia, scarring alopecia, telogen effluvium)
- Diagnosed with scalp diseases or systemic diseases affecting hair loss assessment (e.g., psoriasis, dermatitis, lupus erythematosus, thyroiditis)
- Previously treated with ritlecitinib or other JAK inhibitors
- Investigator site staff, Pfizer employees involved in the study, or their family members
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 96 weeks from treatment initiation
Participants receive ritlecitinib as prescribed in real-world practice and are observed for clinical outcomes and treatment effectiveness.
Visits at Week 24, 48, 72, and 96 for assessments
Trial Site Locations
Total: 58 locations
1
C2 Research Center
Montgomery, Alabama, United States, 36117
Actively Recruiting
2
CENTER FOR DERMATOLOGY CLINICAL RESEARCH, Inc
Fremont, California, United States, 94538
Actively Recruiting
3
Rao Dermatology
Fresno, California, United States, 93720
Actively Recruiting
4
Cura Clinical Research
Oxnard, California, United States, 93030
Actively Recruiting
5
Stanford
Redwood City, California, United States, 94063
Not Yet Recruiting
6
Southern California Clinical Research
Santa Ana, California, United States, 92701
Actively Recruiting
7
Dermatology of Boca
Boca Raton, Florida, United States, 33431
Actively Recruiting
8
Pediatric Skin Research,LLC
Coral Gables, Florida, United States, 33146
Actively Recruiting
9
Suncoast Skin Solutions
Jacksonville, Florida, United States, 32256
Actively Recruiting
10
University of Miami
Miami, Florida, United States, 33136
Actively Recruiting
11
Skin Research of South Florida LLC
Miami, Florida, United States, 33173
Actively Recruiting
12
Kindred Hair and Skin Center
Marriottsville, Maryland, United States, 21104
Actively Recruiting
13
Brigham & Women's Hospital/Harvard Medical School
Boston, Massachusetts, United States, 02115
Actively Recruiting
14
Oakland Hills Dermatology
Auburn Hills, Michigan, United States, 48326
Actively Recruiting
15
Michigan Dermatology Institute
Waterford, Michigan, United States, 48328
Actively Recruiting
16
Twin Cities Dermatology Center
Minneapolis, Minnesota, United States, 55416
Active, Not Recruiting
17
Hickory Dermatology Research Center
Hickory, North Carolina, United States, 28602
Actively Recruiting
18
NW Dermatology Institute
Portland, Oregon, United States, 97210
Actively Recruiting
19
UPMC
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
20
Goodlettsville Dermatology Research
Goodlettsville, Tennessee, United States, 37072
Actively Recruiting
21
Epiphany Dermatology
Southlake, Texas, United States, 76092
Actively Recruiting
22
Raven Clinical Reseach
Fairfax, Virginia, United States, 22033
Actively Recruiting
23
Raven Clinical Reseach
McLean, Virginia, United States, 22102
Actively Recruiting
24
Frontier Dermatology
Mill Creek, Washington, United States, 98012
Actively Recruiting
25
Raven Clinical Reseach
Burlington, Wisconsin, United States, 53105
Actively Recruiting
26
Beijing Tongren Hospital
Beijing, China, 100006
Actively Recruiting
27
Peking University First Hospital
Beijing, China, 100034
Actively Recruiting
28
Peking University People's Hospital
Beijing, China, 100044
Actively Recruiting
29
The Fist Hospital of Jilin Province
Changchun, China, 130021
Not Yet Recruiting
30
Xiangya Hospital, Central South University
Changsha, China, 410028
Actively Recruiting
31
Dermatology Hospital of Southern Medical University
Guangzhou, China, 510091
Actively Recruiting
32
Huashan Hospital Affiliated to Fudan University
Shanghai, China, 200040
Actively Recruiting
33
Shanghai Skin Disease Hospital
Shanghai, China, 200443
Actively Recruiting
34
Ch Victor Dupouy
Argenteuil, France, 95100
Not Yet Recruiting
35
CHU de CAEN
Caen, France, 14033
Actively Recruiting
36
Chu Dijon Bourgogne
Dijon, France, 21000
Not Yet Recruiting
37
CHU de Grenoble Alpes
La Tronche, France, 38700
Not Yet Recruiting
38
CHU de Rennes Hôpital Pontchaillou
Rennes, France, 35000
Not Yet Recruiting
39
Rouen University Hospital
Rouen, France, 76000
Actively Recruiting
40
Centre Sabouraud
Paris, Île-de-France Region, France, 75010
Not Yet Recruiting
41
Hospital of the University of Occupational and Environmental Health
Kitakyushu-shi, Fukuoka, Japan, 807-8556
Actively Recruiting
42
Kurume University Hospital
Kurume-shi, Fukuoka, Japan, 830-0011
Actively Recruiting
43
Nagomi Dermatology Clinic
Ebina, Kanagawa, Japan, 243-0432
Actively Recruiting
44
Tohoku University Hospital
Sendai, Miyagi, Japan, 908-8574
Not Yet Recruiting
45
Niigata University Medical & Dental Hospital
Niigata, Niigata, Japan, 951-8520
Actively Recruiting
46
Osaka Metropolitan University Hospital
Osaka, Osaka, Japan, 545-0051
Actively Recruiting
47
Hamamatsu University Hospital
Hamamatsu, Shizuoka, Japan, 431-3192
Actively Recruiting
48
Juntendo University Hospital
Bunkyo-ku, Tokyo, Japan, 113-8431
Actively Recruiting
49
Teikyo University Hospital
Itabashi-Ku, Tokyo, Japan, 173-8606
Not Yet Recruiting
50
Tokyo Medical University Hospital
Shinjuku-Ku, Tokyo, Japan, 160-0023
Not Yet Recruiting
51
University Hospitals Sussex
Brighton, EAST Sussex, United Kingdom, BN2 3EW
Not Yet Recruiting
52
NHS Fife
Dunfermline, FIFE, United Kingdom, KY120SU
Not Yet Recruiting
53
Gloucestershire Hospitals NHS Foundation Trust
Gloucester, Gloucestershire, United Kingdom, GL13PX
Actively Recruiting
54
Royal United Hospital Bath
Bath, United Kingdom, BA1 3NG
Actively Recruiting
55
NHS Greater Glasgow and Clyde
Glasgow, United Kingdom, G4 0SF
Actively Recruiting
56
Whipps Cross (Barts Health)
London, United Kingdom, E11 1NR
Actively Recruiting
57
London North West University Healthcare Trust
London, United Kingdom, NW10 7NS
Actively Recruiting
58
Chelsea and Westminster NHS Foundation Trust
London, United Kingdom, SW10 9NH
Actively Recruiting
Research Team
P
Pfizer CT.gov Call Center
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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