Actively Recruiting
Characterization of Clinical Phenotypes of Laryngeal Dystonia and Voice Tremor
Led by Massachusetts Eye and Ear Infirmary · Updated on 2025-12-02
165
Participants Needed
1
Research Sites
251 weeks
Total Duration
On this page
Sponsors
M
Massachusetts Eye and Ear Infirmary
Lead Sponsor
U
University of Utah
Collaborating Sponsor
AI-Summary
What this Trial Is About
The researchers will systematically evaluate current and novel clinical voice assessment tools and measures to elucidate distinct clinical phenotypes of those with laryngeal dystonia and voice tremor.
CONDITIONS
Official Title
Characterization of Clinical Phenotypes of Laryngeal Dystonia and Voice Tremor
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females of diverse racial and ethnic backgrounds
- Age 18-80 years
- Native English speakers
- Right-handed
- Normal cognitive status
- Patients with laryngeal dystonia or voice tremor
- Healthy controls without neurological, psychiatric, or otolaryngological problems
You will not qualify if you...
- Unable to give informed consent
- Pregnant or breastfeeding women until no longer pregnant or breastfeeding
- Positive pregnancy test before MRI for women of childbearing potential
- History of neurological problems such as stroke, brain tumors, movement disorders (except specified LD and VT), traumatic brain injury with loss of consciousness, ataxias, myopathies, myasthenia gravis, demyelinating diseases
- History of psychiatric disorders including schizophrenia, bipolar depression, obsessive-compulsive disorder, alcoholism, drug dependence
- Laryngeal problems like vocal fold paralysis, paresis, nodules, polyps, carcinoma, chronic laryngitis
- Other forms of dystonia
- Dystonia symptoms at rest or mirror dystonia
- Patients not symptomatic due to recent botulinum toxin treatment (must be at least 3 months post-injection and fully symptomatic)
- Use of medications affecting the central nervous system
- History of head or neck surgery affecting regional anatomy or innervation
- Presence of tattoos or ferromagnetic objects incompatible with MRI (e.g., implanted stimulators, surgical clips, prosthesis, artificial heart valve)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts Eye and Ear and University of Utah
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
K
Kristina Simonyan, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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