Actively Recruiting
Characterization of Diseases With Salivary Gland Involvement
Led by National Institute of Dental and Craniofacial Research (NIDCR) · Updated on 2026-05-08
1150
Participants Needed
1
Research Sites
886 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: \- Salivary glands in and around the mouth and throat make saliva. Salivary gland disorders can affect a person s quality of life. Studying people who have a disease that affects their salivary gland(s) may teach researchers about the disorders and their genetics. Objectives: \- To study salivary gland diseases and disorders. To collect data and samples from people with salivary gland problems and their relatives. Eligibility: * People more than 4 years old who have or are suspected to have a disease involving salivary glands. * Their relatives more than 4 years old. * Healthy volunteers 18 years or older. Design: * Participants may be screened with: * Medical history * Physical exam * Blood and urine tests * General oral and dental history and exam * Saliva collection * Eye exam and test for dry eyes * Health questionnaires (adults) * Biopsy of some minor salivary glands. A small incision will be made on the inside of the lower lip and several tiny salivary glands will be removed. * Participants will have 2-3 visits. These may include: * Repeats of some screening tests * Ultrasounds of some glands. Researchers will put some gel on the face, then press on it with a smooth wand. * Adults may have other biopsies * A small catheter inserted into the opening of the parotid gland duct on the inside of the cheek. A saline solution (in a syringe) will fill the duct. * Swishing a saltwater solution in the mouth for 10 seconds and then spitting into a cup * Scrapings collected from teeth, tongue, and cheeks
CONDITIONS
Official Title
Characterization of Diseases With Salivary Gland Involvement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Persons older than 4 years of age, affected with or suspected to have a disease involving the salivary glands or who are relatives of such persons
- Persons 18 years or older with active hepatitis, with or without sicca symptoms
- Patients undergoing immunotherapy with an immune checkpoint inhibitor for oral cancer, seen before and after therapy
- Healthy persons age 18 or older who agree to have blood, urine, saliva, or tissue samples collected and studied
You will not qualify if you...
- Unable to give consent or lacking parental/guardian consent
- NIH employees reporting directly to the principal investigator
- Significant medical conditions or circumstances affecting ability to complete the study, such as concurrent chemotherapy or bleeding disorders
- For immune checkpoint inhibitor patients: inability to tolerate study procedures like biopsies or saliva collection
- For healthy volunteers: pregnancy
- For healthy volunteers: sicca symptoms
- For healthy volunteers: HIV, hepatitis B or C infection
- For healthy volunteers: chronic medical illness except well-controlled hypertension or hyperlipidemia
- For healthy volunteers: chronic use of medications except oral contraception, hormone replacement therapy, aspirin, antihypertensives, or antilipemics
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
E
Eileen M Pelayo
CONTACT
M
Margaret E Beach, P.A.-C
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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