Actively Recruiting
Characterization of the Gut Microbiota Signature According to Physical Fitness and Its Implications for Intestinal Health.
Led by University of Rennes 2 · Updated on 2025-12-24
30
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The gut microbiota comprises all microorganisms inhabiting the digestive tract, evolving throughout life under the influence of various intrinsic and extrinsic factors. Under healthy conditions, the microbiota remains stable, resilient, and maintains a symbiotic relationship with its host. Conversely, dysbiosis refers to an alteration in microbial composition and function, which has been linked to diseases such as inflammatory bowel disease (IBD). IBD, including Crohn's disease and ulcerative colitis, is associated with a disrupted microbiota compared to healthy individuals, leading to impaired intestinal barrier integrity and activation of local inflammatory pathways. Increasing evidence also suggests that the gut microbiota of athletes differs from that of physically inactive individuals, showing greater microbial diversity and higher concentrations of short-chain fatty acids (SCFAs). In this context, the present clinical study aims to characterize the bacterial metagenome of the gut microbiota across a continuum ranging from inactive individuals to elite athletes with high or very high energy demands. The ultimate goal of this project is to determine whether specific gut microbiota composition and functional profiles are associated with different levels of exercise capacity, and to create a fecal microbiota biobank for future research on intestinal health.
CONDITIONS
Official Title
Characterization of the Gut Microbiota Signature According to Physical Fitness and Its Implications for Intestinal Health.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male participant
- Age between 18 and 30 years (inclusive)
- Body Mass Index (BMI) between 18 and 25 kg/m² (inclusive)
- No history of gastrointestinal disease, including inflammatory bowel disease
- Non-smoker
- Regular bowel transit with 1-2 bowel movements per day or every other day without recurrent diarrhea or constipation
- Provided free, informed, and written consent
- Training status:
- Low to moderate active subjects: 2 to 4 hours per week of moderate to vigorous physical activity (VO2max 40-50 mL·min⁻¹·kg⁻¹)
- Trained subjects: 5 to 7 hours per week of regular endurance training for at least one year (VO2max 50-65 mL·min⁻¹·kg⁻¹)
- Highly trained subjects: At least 10 hours per week of structured endurance training with daily or twice-daily sessions (VO2max >65 mL·min⁻¹·kg⁻¹)
You will not qualify if you...
- History of cardiovascular disease
- Presence of a metabolic disorder such as diabetes
- Use of antibiotics, antifungal, or antiparasitic agents within the past 3 months or planned use during the study
- Use of prebiotic or probiotic supplements within 7 days before the study providing ≥10⁸ CFU organisms per day
- Current use of medication for chronic pain management including paracetamol, vasodilators, homeopathic treatments, or aspirin at doses >500 mg/day
- Participation in another clinical study involving human subjects or recent participation where the exclusion period has not expired
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Rennes 2 - Laboratory "Movement, Sport and health Sciences"
Bruz, Britanny, France, 35170
Actively Recruiting
Research Team
F
Frédéric DERBRE, PhD
CONTACT
E
Eglantine LE CHEVERT, M.S.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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