Actively Recruiting
Characterization of Gut and Tongue Coating Microbiota in Patients With Diminished Ovarian Reserve
Led by Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University · Updated on 2025-08-26
200
Participants Needed
1
Research Sites
48 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to investigate the distinct tongue manifestation characteristics in patients with diminished ovarian reserve (DOR) compared to healthy individuals, and to clarify the features of tongue coating microbiota, gut microbiota, and their interrelationships in DOR patients. The main question it aims to answer is: Whether there are significant differences in tongue manifestations, tongue coating microbiota, and gut microbiota characteristics between DOR patients and healthy populations; Whether associations exist between tongue coating microbiota and gut microbiota in DOR patients; Whether the pathogenesis of DOR may influence estrogen metabolism through alterations in oral and gut microbiota.
CONDITIONS
Official Title
Characterization of Gut and Tongue Coating Microbiota in Patients With Diminished Ovarian Reserve
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients aged >20 years
- Diagnosis of diminished ovarian reserve with AMH <1.1 ng/mL plus at least one of the following: FSH >10 IU/L, FSH/LH ratio >3.0, or AFC <5-7 follicles measured on menstrual days 2-3
- Conscious with intact cognitive and language abilities to follow study procedures
- Provided written informed consent approved by the Ethics Committee of Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University
You will not qualify if you...
- Female participants aged <20 years
- Women who are menopausal, pregnant, or breastfeeding
- Presence of severe chronic diseases or comorbidities affecting drug efficacy
- Severe primary cardiovascular, liver, kidney, blood, or psychiatric disorders
- Non-compliance with medication protocols or incomplete study data
- Use of sex hormone therapy within the past 3 months
- Diagnosis of reproductive system cancers
- Gastrointestinal disorders or abnormal liver function
- Poor adherence to study protocols or lost to follow-up
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hangzhou TCM Hospital of Zhejiang Chinese Medical University
Hangzhou, Zhejiang, China, 310007
Actively Recruiting
Research Team
W
Wenjun Xiao
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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