Study of Heart Failure With Preserved Ejection Fraction and Related Heart Conditions Evaluating Cardiac Structure, Function, and Prognosis Using Cardiac MRI

What this Trial Is About

Researchers are investigating the mechanisms behind heart failure with preserved left ventricular ejection fraction HFpEF, a common and complex form of heart failure that affects more than half of all heart failure cases. This study aims to understand how heart structure, function, and fibrosis markers change across different stages of heart failure, and how risk factors like hypertension, diabetes, obesity, and kidney problems affect the disease progression. Researchers also want to identify factors that predict outcomes for HFpEF patients by following them over time and comparing clinical data with heart imaging and biomarkers. The study involves three groups patients with HFpEF, patients with heart failure with reduced ejection fraction HFrEF, and healthy control subjects without heart disease. Eligible heart failure patients must be 50 years or older, have specific heart function measurements, symptoms, and recent hospitalization or elevated heart-related biomarkers. Participants will undergo cardiac magnetic resonance imaging cMR to assist diagnosis and evaluate heart structure and function. Control subjects will be recruited across different age decades and will have no heart risk factors or abnormalities on heart tests. Participants will be followed to assess their prognosis, including heart failure hospitalizations or deaths over a six-month period. The study collects data through imaging tests like echocardiography and MRI, blood biomarkers, and clinical evaluations to understand heart failure progression. Researchers will monitor heart function and health outcomes to determine how well imaging and biomarker measures predict future cardiovascular events. The total study duration spans several years, beginning in 2014 and ending in 2028.

Characterization of Heart Failure With Preserved Ejection Fraction