Characterization of Liver Problems in Turner Syndrome Observational Study of Causes and Liver Assessments

What this Trial Is About

This research aims to explore the frequency and causes of liver changes in adult women diagnosed with Turner Syndrome (TS). The study focuses on identifying biochemical and structural liver abnormalities and understanding the factors that may contribute to liver disease in this population. By investigating these aspects, the study hopes to provide important insights into the development and prognosis of liver problems in TS patients. The study is observational and retrospective, involving adult women with TS who are being monitored over time at the Endocrinology and Diabetes Prevention and Care unit of IRCCS Policlinico S. Orsola in Bologna. Diagnosis of TS was confirmed by karyotype analysis of peripheral blood, typically performed during childhood or adulthood at specialized centers. Participants undergo clinical evaluations including measurement of body parameters, and detailed medical history reviews focusing on metabolic and autoimmune conditions, menstrual cycle history, and hormone replacement therapies. Laboratory tests related to liver function are also conducted as part of the routine clinical assessment. Participants will be involved through ongoing monitoring of their clinical and laboratory data as part of standard care. Researchers will review medical histories and collect data on liver function and related factors to identify any associations with liver disease in TS. The primary outcome measure is factors associated with liver disease at baseline. The study aims to generate new hypotheses about liver disease development and progression in women with Turner Syndrome, contributing valuable etiologic and prognostic information.

Characterization of Hepatopathy in Turner Syndrome: Analysis of Determinants