Actively Recruiting
Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults
Led by University of Pennsylvania · Updated on 2026-02-09
700
Participants Needed
1
Research Sites
338 weeks
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
N
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cellular and humoral immune responses before and after seasonal influenza vaccination will be assessed. Each year, up to 100 participants will be enrolled. To study age-specific differences in immune responses, participants with various years of birth will be enrolled. The investigators hypothesize that humans with different birth years will mount antibody and cellular responses of different specificities following seasonal influenza vaccination.
CONDITIONS
Official Title
Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provision of signed and dated informed consent form
- Willingness to comply with all study procedures and attend all study visits
- Aged 18 years and older
- In good health based on self-reported medical conditions via an online survey
You will not qualify if you...
- Known allergic reactions to components of the study vaccine
- Known latex allergy
- History of severe reactions to previous influenza vaccines
- History of Guillain-Barré syndrome within 6 weeks of a previous influenza vaccine
- Immunosuppression due to illness or treatment, including anticancer therapy within past 36 months
- Treatment with immunoglobulin or blood products within 3 months prior to enrollment
- Active cancer (except stable non-melanoma skin or prostate cancer) or recent hematological malignancy treatment within 5 years
- Long-term use of oral, parenteral, or high-dose inhaled steroids
- Influenza vaccine received within 2 months prior to enrollment
- Any acute or chronic medical condition that makes vaccination unsafe or interferes with study evaluation
- Participation in another experimental agent study within 1 month before enrollment or planned during study
- Intention to donate blood during the study
- Any condition posing unacceptable risk or preventing protocol compliance
- Pregnancy
- Known infection with HIV, hepatitis B, or hepatitis C
- Any condition that may interfere with successful study completion as judged by the principal investigator
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
S
Scott Hensley, PhD
CONTACT
E
Elizabeth Drapeau, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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