Actively Recruiting
Led by National Institute on Alcohol Abuse and Alcoholism (NIAAA) · Updated on 2026-06-01
1000
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are investigating how differences in brain structure relate to personality and behavior in adults with and without alcohol dependence. The study also aims to explore connections between these brain differences and specific genetic variations related to neurotransmitter activity. This observational research involves both inpatient individuals diagnosed with alcohol use disorder and non-treatment seeking adult volunteers. Participants will undergo brain imaging assessments, including a variety of MRI scans such as whole brain structural MRI, Diffusion Tensor MRI, and resting state functional MRI, while performing computerized cognitive, motivational, and emotional tasks. These assessments help characterize brain behavior, structure, function, and connectivity related to addiction stages. The study includes groups of individuals currently in alcohol use treatment and those not seeking treatment. During a study visit at the NIH Clinical Center, participants will complete screening procedures including medical history, physical exam, EKG, blood and urine tests, and a psychiatric interview. They will also be asked about their alcohol use and play computerized games, some while inside an MRI scanner. Researchers will measure brain imaging signals linked to addiction phases, analyze genetic and behavioral data, and monitor task performance. The total participation involves one or more visits with detailed assessments to understand the brain and behavioral factors associated with alcoholism.
CONDITIONS
Characterization Imaging Instruments in Alcoholics and Non-Alcoholics
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You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 to multiple visits over an unspecified period
Participants undergo imaging assessments including multiple MRI scans and computerized tasks to characterize brain structure and function related to alcohol use disorder.
1 or more visits including MRI scans and computerized tasks
Duration - Unspecified duration with multiple sessions
Participants may have follow-up imaging and behavioral assessments to observe changes over time in brain and genetic factors associated with alcohol use disorder.
Multiple sessions over time
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
B
Beth A Lee, R.N.
N
Nancy Diazgranados, M.D.
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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