Brain Imaging and Behavioral Study to Understand Alcohol Use Disorder and Genetic Influences

What this Trial Is About

Researchers are studying how differences in brain structure and function relate to personality and behavior in adults with and without alcohol use disorder. This observational study aims to identify brain, behavioral, genetic, and other factors associated with alcoholism by using a set of imaging assessments called Characterization Imaging Instruments for Addiction Neuroimaging Assessments CII-ANiA. The study includes adult volunteers diagnosed with alcohol dependence or alcohol use disorder based on established criteria. Participants will have one or more visits that may include several MRI scans, such as whole brain structural MRI, Diffusion Tensor MRI, and resting state and task-based functional MRIs, while they perform computerized motivational, cognitive, and emotional tasks. The MRI scans involve lying in a scanner for about 90 minutes, which makes loud knocking noises. Some participants will play computerized games inside the MRI scanner, while others may complete behavioral tasks outside the scanner. During the study visit, participants undergo screening including medical history, physical exam, EKG, and provide blood and urine samples. They will be assessed for alcohol use disorder through interviews and questionnaires. Researchers measure brain imaging outcomes related to addiction phases, along with behavioral and genetic data. The study monitors safety through breath alcohol, drug, and pregnancy tests, and excludes participants based on MRI safety and alcohol withdrawal symptoms. Participation involves a single visit with comprehensive assessments to understand the brain and behavior differences linked with alcohol use disorder.

Characterization Imaging Instruments in Alcoholics and Non-Alcoholics