Study of Brain and Body Responses to Pain in Children and Adults With Intellectual Disability Compared to Healthy Volunteers

What this Trial Is About

Researchers are studying how people with intellectual disability ID respond to unpleasant sensations compared to those without ID. The study aims to better understand brain activity and pain perception in individuals aged 8 to 30 years. This is important because people with ID often have physical disabilities that can cause pain, but little research has focused on their experience of pain. Participants will undergo tests measuring brain activity using devices like EEG and functional near-infrared spectroscopy. They will experience different stimuli such as heat, cold, brushing, and mild electrical sensations applied to their body. The study compares brain responses and physiological reactions like heart rate and skin conductance between individuals with ID and healthy controls. The devices include a thermal stimulator to deliver these sensations, and measurements will be taken from sensors placed on the head, chest, fingers, and breathing. Participants will have one visit lasting up to four hours, or those with ID may attend up to five shorter visits. They will complete assessments including physical exams, questionnaires about pain and sensory responses, and social behavior. Caregivers may assist with answering questions if needed. Researchers will measure brain activation, physiological signals, and behavioral responses to understand pain perception. This study aims to provide objective measures of pain in people with ID and healthy volunteers.

Characterization of Nociception Phenotype in Individuals With Intellectual Disability