Study of the Nrf2 Antioxidant Response and Oxidative Stress in Adults Aged 18 to 30 with Autosomal Dominant Polycystic Kidney Disease

What this Trial Is About

Researchers are studying oxidative stress and the Nrf2 antioxidant response in the early stages of Autosomal Dominant Polycystic Kidney Disease ADPKD to better understand how these factors contribute to the disease. The study aims to identify potential biomarkers that could help in developing more specific and effective treatments for ADPKD. This research focuses on how cellular stress signals and antioxidant defenses work in this kidney condition. Participants include individuals diagnosed with early-stage ADPKD and healthy controls matched by age and gender. The study involves collecting blood and urine samples to measure oxidative stress markers and antioxidant activity. Additionally, participants will undergo an abdominal MRI to measure total kidney volume TKV, which helps assess disease progression. During the study, researchers will evaluate oxidative status, antioxidant responses, and kidney injury markers at baseline. The MRI scans and biological samples will provide detailed information about kidney health and redox balance. Participants will be involved in these assessments at the start of the study, and the research team will monitor these factors closely to understand their role in ADPKD.

Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)