Actively Recruiting
Characterization of the Temporo-masseteric Nerve Block (TMNB) in Healthy Subjects
Led by Rutgers, The State University of New Jersey · Updated on 2025-12-05
20
Participants Needed
1
Research Sites
216 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The proposed pilot study is aimed at preliminary characterization of the TMNB injection in 20 healthy volunteers. Assessment of bite-force distribution and surface electromyographic activity of the temporalis and the masseter muscles, at rest and clench, before and after unilateral TMNB injection, will be the primary outcome measures. Post-injection assessments will be performed at 30 minutes, 2 hours, and 2 weeks after the injection. Participants will be surveyed regarding their experience receiving the TMNB injection (secondary outcomes).
CONDITIONS
Official Title
Characterization of the Temporo-masseteric Nerve Block (TMNB) in Healthy Subjects
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 64 years
- Any ethnicity
- Male or female sex
- Fluent in written and spoken English
- Never diagnosed with temporomandibular disorders (TMD)
- No significant history of orofacial pain
- Fewer than 5 headaches per month in the last 3 months
- No reported use of nightguard or occlusal splint
- No jaw or temple pain in the last 30 days
- No stiffness or pain in jaw upon awakening in the last 30 days
- No increase or reduction in jaw/temple pain during chewing, mouth movements, clenching, grinding, chewing gum, or jaw activities like talking, kissing, or yawning
You will not qualify if you...
- Facial or jaw trauma or surgery within the last 6 months
- Current orthodontic treatment
- Pregnant or nursing
- Kidney failure or on renal dialysis
- Heart disease or heart failure
- Uncontrolled chronic respiratory disease, hypertension, or diabetes
- History of seizures
- Hyperthyroidism
- Drug or alcohol abuse
- Psychiatric disorders requiring hospitalization
- Undergoing chemotherapy or radiation therapy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Rutgers School of Dental Medicine
Newark, New Jersey, United States, 07103
Actively Recruiting
Research Team
G
Gayathri D Subramanian
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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