Actively Recruiting
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
Led by University of Southern California · Updated on 2025-11-25
120
Participants Needed
2
Research Sites
634 weeks
Total Duration
On this page
Sponsors
U
University of Southern California
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study that originally launched in 2015, enrolling 133 participants. From the originally enrolled participants, the continuation of the ADNI-D study will enroll 120 participants which will include following participants from the original (parent) protocol and enrollment of new participants for a period of 30 months. Data from an additional 300 non-depressed subjects will be used from ADNI studies for comparison. Depression history, symptom severity and health information will be collected at the initial visit to determine eligibility. An magnetic resonance imaging (MRI) scan, as well as amyloid (florbetapir) and tau (flortaucipr) positron emission tomography (PET) imaging will be conducted at San Francisco VA. Collection of plasma and serum for biomarkers, clinical assessments and cognitive assessments will be conducted at two time points. Blood samples will also be collected for genetic analysis.
CONDITIONS
Official Title
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participated in the original Characterizing Cognitive Decline in Late Life Depression study or the Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression study
You will not qualify if you...
- Antidepressant medication dose must be stable for at least 4 weeks before the MRI scan
- Completed at least 4 weeks of individual or group psychotherapy before the MRI scan
- Taking cognitive enhancing medications is allowed
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University of California, San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
2
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
Completed
Research Team
N
Nithya Ganesh
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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