The relationship of medical comorbidity and depression in older, primary care patients.
Jeffrey M Lyness, Aurelian Niculescu, Xin Tu...
https://pubmed.ncbi.nlm.nih.gov/16959933Actively Recruiting
Age: 65Years +
All Genders
ID02434393
Characterizing Cognitive Decline in Late Life Depression: The Alzheimer's Disease Neuroimaging Initiative - Depression Project
Led by University of Southern California · Updated on 2025-11-25
120
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Southern California
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the factors that contribute to cognitive impairment and faster cognitive decline in people with Late Life Depression (LLD). This observational research aims to understand these changes without providing treatment. The study began in 2015, initially enrolling 133 participants, and will continue by enrolling 120 participants over 30 months, including both continuing participants and new enrollees. Data from 300 non-depressed individuals will be used for comparison. Participants with Major Depression or Late Life Depression will be followed without treatment. Assessments will include magnetic resonance imaging (MRI) scans and positron emission tomography (PET) scans for amyloid and tau proteins. Blood samples will be collected for genetic and biomarker analysis. Clinical and cognitive tests will be done at two time points during the study. Participants will undergo evaluations including depression history, symptom severity, and health information at the start. They will have brain scans and blood drawn at specified visits. Researchers will measure changes in memory, executive function, language skills, brain structure, and protein deposits over five years. Genetic studies using collected data will also be conducted. The study is planned to continue through May 2027.
CONDITIONS
Brief Title
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
Who Can Participate
Age: 65Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Individual participated in original Characterizing Cognitive Decline in Late Life Depression study or Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression Study.
- Antidepressant medication treatment is allowed only if the medication dose is stable for 4 weeks prior to the MRI scan.
- Psychotherapy interventions are allowed only if participants have completed at least 4 weeks of individual or group psychotherapy prior to the MRI scan.
- Participants taking cognitive enhancing medications may enter the study.
You will not qualify if you...
- None specified beyond inclusion exceptions; stable medication and psychotherapy requirements must be met.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - 5 years
Participants undergo assessments including neuropsychological tests, MRI scans, and biomarker measurements to characterize cognitive decline.
Regular assessments during the 5-year period
Long-term Monitoring
Duration - 5 years
Participants are monitored over time to track changes in cognitive function and brain structure.
Periodic visits for follow-up assessments during the 5-year period
Trial Site Locations
Total: 2 locations
1
University of California, San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
2
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
Completed
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Research Team
N
Nithya Ganesh
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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T Gabryelewicz, M Styczynska, E Luczywek...
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L Ganzini, D M Smith, D S Fenn...
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