Study of Cognitive Decline in Older Adults with Late Life Depression using Brain Imaging and Biomarkers

What this Trial Is About

Researchers are studying the factors that contribute to cognitive impairment and faster cognitive decline in people with Late Life Depression LLD. This observational research aims to understand these changes without providing treatment. The study began in 2015, initially enrolling 133 participants, and will continue by enrolling 120 participants over 30 months, including both continuing participants and new enrollees. Data from 300 non-depressed individuals will be used for comparison. Participants with Major Depression or Late Life Depression will be followed without treatment. Assessments will include magnetic resonance imaging MRI scans and positron emission tomography PET scans for amyloid and tau proteins. Blood samples will be collected for genetic and biomarker analysis. Clinical and cognitive tests will be done at two time points during the study. Participants will undergo evaluations including depression history, symptom severity, and health information at the start. They will have brain scans and blood drawn at specified visits. Researchers will measure changes in memory, executive function, language skills, brain structure, and protein deposits over five years. Genetic studies using collected data will also be conducted. The study is planned to continue through May 2027.

Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project