What is this study trying to find out about prostate cancer?

This study is analyzing tumor tissue from Native American patients with prostate cancer to understand how different genes affect treatment decisions, cancer progression, and outcomes. The research aims to create a comprehensive database to support future personalized treatments. The University of Oklahoma is leading this research with community oversight to ensure cultural sensitivity.

Who may be eligible for this prostate cancer clinical trial?

Men aged 18 to 100 who identify as Native American and have been diagnosed with prostate cancer may be eligible. Participants must have archived tumor tissue samples available for analysis. Please review eligibility criteria for more details.

Is there any cost to participate in this prostate cancer clinical trial?

Study-related care, including sample collection and all trial visits, is provided at no cost. Personal travel expenses may vary and are not guaranteed to be covered.

Actively Recruiting

Age: 18Years - 100Years

MALE

ID06960798

Characterizing the Genomic Landscape of Prostate Cancer in Native American Populations Nat-Geno

Led by University of Oklahoma · Updated on 2026-03-02

150

Participants Needed

Research Sites

56 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are studying prostate cancer in Native American patients to understand how different genes in tumor tissue affect treatment choices, cancer progression, and outcomes. The study focuses on creating a detailed database of Native American patients diagnosed with prostate cancer by examining the genetic makeup of their tumors. This research aims to provide insights that may guide future personalized treatments. Participants will provide archived tumor tissue samples collected at screening, and blood samples will be drawn within the first year of enrollment. The study will analyze these samples using whole exome sequencing and whole transcriptome sequencing to explore the genetic and transcriptomic characteristics of the cancer. Initially, patients will be enrolled at the Stephenson Cancer Center, with plans to expand to other sites in Oklahoma and across the United States. Oversight is maintained by a Tribal Institutional Review Board and a Community Advisory Board to ensure cultural sensitivity and community involvement. During the study, researchers will collect and analyze tumor and blood samples, focusing on genomic differences in prostate cancer over 1 to 3 years. Participants may undergo assessments related to tissue and blood collection but will not receive experimental treatments since this is an observational study. The total participation time varies, with evaluations occurring mostly within the first year. The study aims to gather data that could help tailor prostate cancer treatments specifically for Native American populations.

CONDITIONS

Brief Title

Characterizing the Genomic Landscape of Prostate Cancer in Native American Populations (NAT-Geno)

Who Can Participate

Age: 18Years - 100Years

MALE

Eligibility Criteria

You may qualify if you...

Written informed consent signed and dated by the patient before any study procedures.
At least 18 years old at the time of consent.
Self-identify as Native American.
Pathologically confirmed diagnosis of prostate cancer at any stage.
Availability of the most recent archived tumor tissue samples.

You will not qualify if you...

Not of Native American descent or identity.
No archived tumor tissue samples available.

Research Team

Lead Onco Nurse

Adanma Ayanambakkam, MD

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here