Actively Recruiting
Characterizing Matrix Metalloproteinase-12 (MMP12) in Sputum
Led by McMaster University · Updated on 2024-11-20
45
Participants Needed
1
Research Sites
109 weeks
Total Duration
On this page
Sponsors
M
McMaster University
Lead Sponsor
F
Foresee Pharmaceuticals Co., Ltd.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The hypothesis is that in patients with emphysema, a high MMP12 sputum and/or blood level correlates with airspace enlargement and with increased sputum Th2 immune biomarkers.
CONDITIONS
Official Title
Characterizing Matrix Metalloproteinase-12 (MMP12) in Sputum
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 40 years or older
- Current or former smokers with more than 10 pack years smoking history
- Post-bronchodilator FEV1/FVC ratio less than 70% and post-bronchodilator FEV1 of 30% predicted or higher (GOLD 1, 2, and 3)
- Radiologist confirmed emphysema diagnosis based on CT scan
- For normal controls: no significant medical or respiratory conditions, no smoking history, and post-bronchodilator FEV1/FVC ratio greater than 70%
You will not qualify if you...
- Presence of non-COPD airway diseases
- Very severe COPD with FEV1 less than 30% predicted
- Current exacerbation of lung disease
- Life expectancy less than 3 months
- Pregnancy or breastfeeding
- Receiving immunomodulatory or biologic treatments
- Use of systemic steroids in the last month
- Hospitalization due to exacerbation in the past 12 months
- Known cardiovascular disease under treatment or hospitalization in the past year
- Unable to perform spirometry
- Active cancer
- Lung surgery during the study period
- History of alcohol or drug abuse affecting study compliance
- History of bronchial thermoplasty
- Participation in another clinical study simultaneously
- Presence of implanted devices or metal in the body incompatible with MRI, such as pacemakers, artificial limbs, metallic fragments, shunts, surgical staples, or ear implants
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Firestone Institute for Respiratory Health, St. Joseph's Healthcare
Hamilton, Ontario, Canada, L8N 4A6
Actively Recruiting
Research Team
S
Sarah Svenningsen, PhD
CONTACT
M
Melanie Kjarsgaard
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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