Actively Recruiting
Chardonnay Marc and Vascular Response
Led by University of California, Davis · Updated on 2026-02-18
5
Participants Needed
1
Research Sites
207 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to obtain data on the potential influence of Vine to Bar product(s) containing Chardonnay marc on cardiometabolic health. These initial studies will inform the design and timing of data collection for future dietary intervention trials that will examine the influence of Chardonnay marc intake on outcomes/biomarkers of both cardiometabolic health and the gut microbiome. This includes collecting data on the potential differences in response to the products based on the unique food matrix for each of the products that will be tested. Moreover, as there is a paucity of data on the influence of cocoa flavanol intake on vascular function beyond 4 hours post intake, the response of the selected outcomes will be assessed after 6 hours of flavanol intake. This is a time point that captures the increased circulating presence of microbial derived flavanol metabolites.
CONDITIONS
Official Title
Chardonnay Marc and Vascular Response
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Screening or Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) < 2.0
- Willing and able to comply with study protocols
- Willing to participate in all study procedures
- Body Mass Index (BMI) between 25.0 and 35 kg/m2
You will not qualify if you...
- Body Mass Index (BMI) 35 kg/m2 or higher
- Weight less than 110 lbs
- Donated blood within the previous 30 days
- Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) of 2.0 or higher
- Collagen screening maximal platelet aggregatory response less than 65% at 1 and 3 ug/ml
- Platelet counts less than 150,000 / ul
- Anemia based on self-report or blood test results
- Allergy or dislike for nuts, cocoa, or grape products
- Daily use of anticoagulation agents including aspirin or NSAIDs
- Vegan, vegetarian, food faddist, or non-traditional diet
- Fruit consumption 3 cups or more per day
- Vegetable consumption 4 cups or more per day
- Nut intake 2 servings or more per week
- Coffee or tea consumption 3 cups or more per day
- Dark chocolate consumption 3 oz or more per day
- Restricted physical activity due to chronic health condition
- Chronic or routine high intensity exercise
- Self-reported diabetes
- Blood pressure 140/90 mm Hg or higher
- Self-reported kidney or liver disease
- Self-reported heart disease including cardiovascular events or stroke
- Peripheral artery disease or Raynaud's syndrome
- Inability to wear PAT probes or abnormal pre-screening PAT measurements
- Cancer within past 5 years
- Malabsorption
- Currently taking prescription drugs or supplements
- Use of supplements including herbal, botanical, fish oil, or oil supplements within 1 month prior to enrollment
- Substance or alcohol abuse within the last 3 years
- Smoking, vaping, or cannabis use
- Currently enrolled in another clinical research study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Academic Surge, University of California, Davis
Davis, California, United States, 95616
Actively Recruiting
Research Team
R
Roberta R Holt
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
5
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