Study on the Effects of Chardonnay Marc and Cocoa Flavanols on Metabolic and Vascular Health in Men Aged 30 to 50

What this Trial Is About

Researchers are evaluating how products containing Chardonnay marc, combined with cocoa flavanols, affect heart and metabolic health. This research focuses on measuring how these products influence blood vessel function and related health markers, including the gut microbiome, in adult males aged 30 to 50. The study aims to gather data that will help design future dietary trials and understands how different product forms impact the bodys response, especially 6 hours after consumption when certain metabolites peak in the bloodstream. The study uses a randomized, double-blind, crossover design involving up to 5 participants. Each participant will consume different test products on separate occasions low flavanol cocoa powder, high flavanol cocoa powder, and various servings of Vine to Bar Chocolate containing both cocoa flavanols and Chardonnay marc, including a version with almonds. Responses will be measured after single intakes followed over 6 hours to compare effects across these products. Participants will undergo assessments including the Framingham Reactive Hyperemia Index fRHI at 6 hours, along with tests for platelet aggregation, oxidative enzymes, glucose, insulin, and nitrate levels. The study involves close monitoring of vascular and metabolic responses after product intake. Participants will follow all procedures and visit schedules as outlined, with the total involvement lasting for the duration of these acute testing visits.

Chardonnay Marc and Vascular Response