Actively Recruiting
Preclinical Trials to Determine the Range of Chardonnay Mark Intake for Improved Metabolic and Vascular Response
Led by University of California, Davis · Updated on 2026-02-18
5
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how products containing Chardonnay marc, combined with cocoa flavanols, affect heart and metabolic health. This research focuses on measuring how these products influence blood vessel function and related health markers, including the gut microbiome, in adult males aged 30 to 50. The study aims to gather data that will help design future dietary trials and understands how different product forms impact the body's response, especially 6 hours after consumption when certain metabolites peak in the bloodstream. The study uses a randomized, double-blind, crossover design involving up to 5 participants. Each participant will consume different test products on separate occasions: low flavanol cocoa powder, high flavanol cocoa powder, and various servings of Vine to Bar Chocolate containing both cocoa flavanols and Chardonnay marc, including a version with almonds. Responses will be measured after single intakes followed over 6 hours to compare effects across these products. Participants will undergo assessments including the Framingham Reactive Hyperemia Index (fRHI) at 6 hours, along with tests for platelet aggregation, oxidative enzymes, glucose, insulin, and nitrate levels. The study involves close monitoring of vascular and metabolic responses after product intake. Participants will follow all procedures and visit schedules as outlined, with the total involvement lasting for the duration of these acute testing visits.
CONDITIONS
Brief Title
Chardonnay Marc and Vascular Response
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Screening or Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) less than 2.0
- Willing and able to comply with study protocols
- Willing to participate in all study procedures
- Body Mass Index (BMI) between 25.0 and 35 kg/m2
- Male aged 30 to 50 years
You will not qualify if you...
- Body Mass Index (BMI) 35 kg/m2 or higher
- Weigh less than 110 pounds
- Donated blood within the previous 30 days
- Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) 2.0 or higher
- Collagen screening maximal platelet aggregatory response less than 65%
- Platelet counts below 150,000 / ul
- Anemia, diagnosed by self-report or blood tests
- Allergy or dislike of nuts, cocoa, or grape products
- Daily use of anticoagulation agents including aspirin or NSAIDs
- Vegan, vegetarian, food faddist, or non-traditional diet
- Fruit consumption 3 cups or more per day
- Vegetable consumption 4 cups or more per day
- Nut intake 2 servings or more per week
- Coffee or tea consumption 3 cups or more per day
- Dark chocolate consumption 3 oz or more per day
- Physical activity restricted due to chronic health condition
- Routine high intensity exercise
- Diabetes by self-report
- Blood pressure 140/90 mm Hg or higher
- Renal or liver disease by self-report
- Heart disease including cardiovascular events and stroke
- Peripheral artery disease or Raynaud's syndrome
- Unable to wear or abnormal measurements with PAT probes
- Cancer within past 5 years
- Malabsorption by self-report
- Use of prescription drugs or supplements
- Use or unwillingness to stop supplements including herbal, plant, fish oil a month before enrollment
- Substance or alcohol abuse in last 3 years
- Smoking, vaping, or cannabis use
- Currently enrolled in another clinical research study
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening visit (in-person)
Duration - Several single intake sessions, each followed for 6 hours
Participants receive single intakes of different cocoa and chocolate products in a crossover design and have their vascular and metabolic responses measured over 6 hours after each intake.
Multiple visits for each intake session, each lasting approximately 6 hours
Trial Site Locations
Total: 1 location
1
Academic Surge, University of California, Davis
Davis, California, United States, 95616
Actively Recruiting
Research Team
R
Roberta R Holt
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
5
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