Actively Recruiting
Chemoradiotherapy for Advanced Esophageal Cancer
Led by AHS Cancer Control Alberta · Updated on 2025-12-16
50
Participants Needed
1
Research Sites
440 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to show that the addition of carboplatin and paclitaxel chemotherapy to a palliative course of external beam radiation treatment improves both dysphagia relief and patient quality of life in patients with unresectable esophageal cancer.
CONDITIONS
Official Title
Chemoradiotherapy for Advanced Esophageal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Biopsy confirmed esophageal cancer
- Not suitable for radical or curative treatment due to advanced disease, metastases, or other illness
- Symptomatic with swallowing difficulty scoring at least Mellow Dysphagia Score 1 (able to eat some solids)
- ECOG performance status of 2 or less
- Able to start treatment within 14 days of signing consent
- At least 18 years old
- Hemoglobin above 100g/L
- Platelet count above 100 x 10^9/L
- Absolute neutrophil count above 1.5 x 10^9/L
- Liver enzymes AST and ALT less than or equal to 2.5 times normal (up to 5 times if liver metastases)
- Total bilirubin less than or equal to 1.5 times normal
- Creatinine clearance at least 50 mL/min (Cockcroft-Gault formula)
- Using adequate contraception if capable of childbearing
- Provided written informed consent
You will not qualify if you...
- Previous chest radiotherapy
- Current active cancers other than esophageal cancer
- Pregnant or breastfeeding
- Women or men of childbearing potential not using effective contraception
- Unfit for any treatment component or having contraindications for radiotherapy or connective tissue disease
- Presence of tracheo-esophageal fistula
- Esophageal stents in place
- Previous chemotherapy for esophageal cancer
- Unable to complete surveys in English without help
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tom Baker Cancer Centre
Calgary, Alberta, Canada, T2N 4N2
Actively Recruiting
Research Team
M
Marilyn David
CONTACT
A
Amy Abel
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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