Actively Recruiting
Chemoradiotherapy in Elderly Patients With Oesophagus Cancer
Led by Centre Hospitalier Universitaire de Besancon · Updated on 2024-01-18
54
Participants Needed
1
Research Sites
684 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Management of elderly patient with cancer is a therapeutic challenge and a public health problem. The mean age of esophageal cancer is 64.5 years and 72.1 years in men and women respectively. Surgery is a standard treatment reserved to about 30 % of patients. The other 70 % are considered unfit for surgery for various reasons, including ageing. Chemoradiotherapy (CRT) is standard treatment for patients with esophageal cancer unfit for surgery. The validated treatment scheme is external beam radiotherapy (EBRT) 50 Gy over 5 weeks combined with cisplatin and 5FU infusion. However it induces high rates of severe and life threatening toxicities: grade 3 haematologic and esophageal mucositis of 20 and 25 % respectively, in patients with a median age of 64 years. CRT has not been properly evaluated in patients more than 75 years, and other combined chemotherapy are challenging.
CONDITIONS
Official Title
Chemoradiotherapy in Elderly Patients With Oesophagus Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Esophageal cancer, squamous or adenocarcinoma types, stages T1-3, N0-1, M1a (TNM 6th edition)
- Age over 75 years
- WHO performance status less than 2
- Balducci score of 1
- Adequate bone marrow reserve
- Normal kidney and liver function
You will not qualify if you...
- Age under 75 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centre Hospitalier Universitaire de Besançon
Besançon, France, 25000
Actively Recruiting
Research Team
J
Jihane BOUSTANI, Dr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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