Actively Recruiting
Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery
Led by ECOG-ACRIN Cancer Research Group ยท Updated on 2026-05-05
82
Participants Needed
140
Research Sites
524 weeks
Total Duration
On this page
Sponsors
E
ECOG-ACRIN Cancer Research Group
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This randomized phase II trial studies how well chemotherapy before surgery and radiation therapy works compared to surgery and radiation therapy alone in treating patients with nasal and paranasal sinus cancer that can be removed by surgery. Drugs used in chemotherapy, such as docetaxel, cisplatin, and carboplatin work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving chemotherapy before surgery and radiation therapy may make the tumor smaller and reduce the amount of normal tissue that needs to be removed and treated with radiation.
CONDITIONS
Official Title
Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- General physical condition suitable for chemotherapy and surgery
- Histologically confirmed nasal and paranasal sinus squamous cell carcinoma (NPNSCC) at stage T3 or T4a requiring orbital or skull base resection
- Surgical oncologist determination of the need for orbit or skull base removal before randomization
- Surgically resectable tumor with a planned assessment of orbit and skull base preservation
- No investigational agents received within 4 weeks before enrollment or during study
- Ability to receive at least one of the proposed chemotherapy regimens
- No evidence of distant metastases or leptomeningeal disease
- No prior radiation to head and neck, skull base, or brain tumors
- Adequate blood counts and kidney and liver function within 2 weeks prior to randomization
- History of curatively treated squamous cell or basal skin carcinoma or in situ cervical cancer allowed
- No peripheral neuropathy greater than grade 2 at randomization
- No severe hypersensitivity to docetaxel or related drugs
- Women must not be pregnant or breastfeeding and must have negative pregnancy test if of childbearing potential
- Use of effective contraception or abstinence during study participation
- Measurable disease confirmed by MRI and/or PET/CT within 2 weeks prior to registration
You will not qualify if you...
- Evidence of distant metastases or leptomeningeal disease
- Prior radiation therapy to head and neck, skull base, or brain tumors
- Uncontrolled inter-current illnesses that prevent chemotherapy or surgery
- History of other malignancies unless disease-free for at least 2 years
- Allergic reactions to docetaxel or platinum-based chemotherapy agents preventing use
- Peripheral neuropathy greater than grade 2
- Current pregnancy or breastfeeding
- Severe hypersensitivity to drugs formulated with polysorbate 80
- Inability to comply fully with study requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 140 locations
1
University of Arizona Cancer Center-Orange Grove Campus
Tucson, Arizona, United States, 85704
Actively Recruiting
2
Banner University Medical Center - Tucson
Tucson, Arizona, United States, 85719
Actively Recruiting
3
University of Arizona Cancer Center-North Campus
Tucson, Arizona, United States, 85719
Actively Recruiting
4
Mercy Hospital Fort Smith
Fort Smith, Arkansas, United States, 72903
Actively Recruiting
5
UC San Diego Moores Cancer Center
La Jolla, California, United States, 92093
Withdrawn
6
Stanford Cancer Institute Palo Alto
Palo Alto, California, United States, 94304
Actively Recruiting
7
VA Palo Alto Health Care System
Palo Alto, California, United States, 94304
Actively Recruiting
8
Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut, United States, 06510
Actively Recruiting
9
Yale University
New Haven, Connecticut, United States, 06520
Actively Recruiting
10
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, United States, 33146
Suspended
11
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, United States, 33442
Actively Recruiting
12
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States, 33136
Actively Recruiting
13
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, United States, 33324
Actively Recruiting
14
Moffitt Cancer Center-International Plaza
Tampa, Florida, United States, 33607
Actively Recruiting
15
Moffitt Cancer Center - McKinley Campus
Tampa, Florida, United States, 33612
Actively Recruiting
16
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Actively Recruiting
17
Emory Proton Therapy Center
Atlanta, Georgia, United States, 30308
Actively Recruiting
18
Emory University Hospital Midtown
Atlanta, Georgia, United States, 30308
Actively Recruiting
19
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, United States, 30322
Actively Recruiting
20
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, United States, 83706
Actively Recruiting
21
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, United States, 83605
Actively Recruiting
22
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho, United States, 83814
Actively Recruiting
23
Idaho Urologic Institute-Meridian
Meridian, Idaho, United States, 83642
Actively Recruiting
24
Saint Alphonsus Medical Center-Nampa
Nampa, Idaho, United States, 83686
Actively Recruiting
25
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, United States, 83854
Actively Recruiting
26
Rush - Copley Medical Center
Aurora, Illinois, United States, 60504
Actively Recruiting
27
Northwestern University
Chicago, Illinois, United States, 60611
Active, Not Recruiting
28
Rush University Medical Center
Chicago, Illinois, United States, 60612
Actively Recruiting
29
Carle on Vermilion
Danville, Illinois, United States, 61832
Actively Recruiting
30
Carle Physician Group-Effingham
Effingham, Illinois, United States, 62401
Actively Recruiting
31
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois, United States, 60201
Actively Recruiting
32
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois, United States, 60026
Actively Recruiting
33
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois, United States, 60035
Actively Recruiting
34
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, United States, 61938
Actively Recruiting
35
Good Samaritan Regional Health Center
Mount Vernon, Illinois, United States, 62864
Actively Recruiting
36
Carle Cancer Center
Urbana, Illinois, United States, 61801
Actively Recruiting
37
The Carle Foundation Hospital
Urbana, Illinois, United States, 61801
Actively Recruiting
38
Saint Anthony Regional Hospital
Carroll, Iowa, United States, 51401
Actively Recruiting
39
Iowa Methodist Medical Center
Des Moines, Iowa, United States, 50309
Actively Recruiting
40
Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa, United States, 50309
Actively Recruiting
41
Broadlawns Medical Center
Des Moines, Iowa, United States, 50314
Actively Recruiting
42
Iowa Lutheran Hospital
Des Moines, Iowa, United States, 50316
Actively Recruiting
43
Methodist West Hospital
West Des Moines, Iowa, United States, 50266-7700
Actively Recruiting
44
Central Care Cancer Center - Garden City
Garden City, Kansas, United States, 67846
Actively Recruiting
45
Central Care Cancer Center - Great Bend
Great Bend, Kansas, United States, 67530
Actively Recruiting
46
University of Kansas Cancer Center
Kansas City, Kansas, United States, 66160
Active, Not Recruiting
47
Lawrence Memorial Hospital
Lawrence, Kansas, United States, 66044
Active, Not Recruiting
48
Olathe Health Cancer Center
Olathe, Kansas, United States, 66061
Active, Not Recruiting
49
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, United States, 66210
Active, Not Recruiting
50
Ascension Via Christi - Pittsburg
Pittsburg, Kansas, United States, 66762
Active, Not Recruiting
51
Salina Regional Health Center
Salina, Kansas, United States, 67401
Active, Not Recruiting
52
University of Kansas Health System Saint Francis Campus
Topeka, Kansas, United States, 66606
Active, Not Recruiting
53
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, United States, 66205
Active, Not Recruiting
54
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky, United States, 40202
Actively Recruiting
55
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, United States, 02114
Suspended
56
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
57
Henry Ford Cancer Institute-Downriver
Brownstown, Michigan, United States, 48183
Actively Recruiting
58
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan, United States, 48038
Actively Recruiting
59
Henry Ford Medical Center-Fairlane
Dearborn, Michigan, United States, 48126
Actively Recruiting
60
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, United States, 48201
Actively Recruiting
61
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Actively Recruiting
62
Weisberg Cancer Treatment Center
Farmington Hills, Michigan, United States, 48334
Actively Recruiting
63
Allegiance Health
Jackson, Michigan, United States, 49201
Actively Recruiting
64
Henry Ford Medical Center-Columbus
Novi, Michigan, United States, 48377
Actively Recruiting
65
Henry Ford Macomb Health Center - Shelby Township
Shelby, Michigan, United States, 48315
Actively Recruiting
66
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, United States, 48322
Actively Recruiting
67
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, United States, 56601
Actively Recruiting
68
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, Missouri, United States, 63011
Actively Recruiting
69
Central Care Cancer Center - Bolivar
Bolivar, Missouri, United States, 65613
Actively Recruiting
70
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, United States, 63376
Actively Recruiting
71
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, United States, 63141
Actively Recruiting
72
Freeman Health System
Joplin, Missouri, United States, 64804
Actively Recruiting
73
Mercy Hospital Joplin
Joplin, Missouri, United States, 64804
Actively Recruiting
74
University of Kansas Cancer Center - North
Kansas City, Missouri, United States, 64154
Active, Not Recruiting
75
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City, Missouri, United States, 64116
Active, Not Recruiting
76
Delbert Day Cancer Institute at PCRMC
Rolla, Missouri, United States, 65401
Actively Recruiting
77
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri, United States, 65401
Actively Recruiting
78
Heartland Regional Medical Center
Saint Joseph, Missouri, United States, 64506
Actively Recruiting
79
Mercy Hospital Springfield
Springfield, Missouri, United States, 65804
Actively Recruiting
80
CoxHealth South Hospital
Springfield, Missouri, United States, 65807
Actively Recruiting
81
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
82
Mercy Hospital South
St Louis, Missouri, United States, 63128
Actively Recruiting
83
Siteman Cancer Center-South County
St Louis, Missouri, United States, 63129
Actively Recruiting
84
Siteman Cancer Center at Christian Hospital
St Louis, Missouri, United States, 63136
Actively Recruiting
85
Mercy Hospital Saint Louis
St Louis, Missouri, United States, 63141
Actively Recruiting
86
Billings Clinic Cancer Center
Billings, Montana, United States, 59101
Actively Recruiting
87
Bozeman Deaconess Hospital
Bozeman, Montana, United States, 59715
Actively Recruiting
88
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana, United States, 59405
Actively Recruiting
89
Great Falls Clinic
Great Falls, Montana, United States, 59405
Actively Recruiting
90
Kalispell Regional Medical Center
Kalispell, Montana, United States, 59901
Actively Recruiting
91
Community Medical Hospital
Missoula, Montana, United States, 59804
Actively Recruiting
92
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
93
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States, 07748
Actively Recruiting
94
Memorial Sloan Kettering Bergen
Montvale, New Jersey, United States, 07645
Actively Recruiting
95
Northwell Health Imbert Cancer Center
Bay Shore, New York, United States, 11706
Actively Recruiting
96
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263
Actively Recruiting
97
Northwell Health/Center for Advanced Medicine
Lake Success, New York, United States, 11042
Actively Recruiting
98
Long Island Jewish Medical Center
New Hyde Park, New York, United States, 11040
Actively Recruiting
99
Lenox Hill Hospital
New York, New York, United States, 10021
Actively Recruiting
100
Mount Sinai Hospital
New York, New York, United States, 10029
Actively Recruiting
101
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
102
University of Rochester
Rochester, New York, United States, 14642
Actively Recruiting
103
Montefiore Medical Center-Einstein Campus
The Bronx, New York, United States, 10461
Actively Recruiting
104
Montefiore Medical Center-Weiler Hospital
The Bronx, New York, United States, 10461
Actively Recruiting
105
Montefiore Medical Center - Moses Campus
The Bronx, New York, United States, 10467
Actively Recruiting
106
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
107
Sanford Bismarck Medical Center
Bismarck, North Dakota, United States, 58501
Actively Recruiting
108
Sanford Broadway Medical Center
Fargo, North Dakota, United States, 58122
Actively Recruiting
109
Sanford Roger Maris Cancer Center
Fargo, North Dakota, United States, 58122
Actively Recruiting
110
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio, United States, 45219
Actively Recruiting
111
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio, United States, 45069
Actively Recruiting
112
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
Active, Not Recruiting
113
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, United States, 73120
Actively Recruiting
114
UPMC-Heritage Valley Health System Beaver
Beaver, Pennsylvania, United States, 15009
Actively Recruiting
115
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg, Pennsylvania, United States, 15601
Actively Recruiting
116
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg, Pennsylvania, United States, 17109
Actively Recruiting
117
UPMC Jameson
New Castle, Pennsylvania, United States, 16105
Suspended
118
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
119
UPMC-Presbyterian Hospital
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
120
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
121
UPMC-Shadyside Hospital
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
122
UPMC-Passavant Hospital
Pittsburgh, Pennsylvania, United States, 15237
Actively Recruiting
123
UPMC Washington Hospital Radiation Oncology
Washington, Pennsylvania, United States, 15301
Actively Recruiting
124
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, United States, 57104
Actively Recruiting
125
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, United States, 57117-5134
Actively Recruiting
126
Parkland Memorial Hospital
Dallas, Texas, United States, 75235
Active, Not Recruiting
127
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, United States, 75390
Active, Not Recruiting
128
UT Southwestern Clinical Center at Richardson/Plano
Richardson, Texas, United States, 75080
Active, Not Recruiting
129
Inova Schar Cancer Institute
Fairfax, Virginia, United States, 22031
Actively Recruiting
130
Inova Fairfax Hospital
Falls Church, Virginia, United States, 22042
Actively Recruiting
131
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, United States, 54701
Actively Recruiting
132
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, United States, 54449
Actively Recruiting
133
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Active, Not Recruiting
134
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin, United States, 54548
Actively Recruiting
135
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, United States, 54868
Actively Recruiting
136
Marshfield Clinic Stevens Point Center
Stevens Point, Wisconsin, United States, 54482
Actively Recruiting
137
Marshfield Clinic-Wausau Center
Wausau, Wisconsin, United States, 54401
Suspended
138
Diagnostic and Treatment Center
Weston, Wisconsin, United States, 54476
Actively Recruiting
139
Marshfield Medical Center - Weston
Weston, Wisconsin, United States, 54476
Actively Recruiting
140
Welch Cancer Center
Sheridan, Wyoming, United States, 82801
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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