Actively Recruiting
Study of Chemotherapy Effects on Thinking and Brain Changes in Women 60 and Older With Breast Cancer
Led by Massachusetts General Hospital · Updated on 2026-07-16
200
Participants Needed
2
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating how chemotherapy affects thinking and brain function in older adults with breast cancer. The study aims to identify chemo-brain, which refers to cognitive changes caused by chemotherapy, and to find people most at risk for these effects. It focuses on assessing thinking abilities and brain images before and after chemotherapy treatment. Participants include three groups breast cancer patients receiving chemotherapy, breast cancer patients not receiving chemotherapy, and healthy volunteers. All participants undergo cognitive and functional assessments along with brain imaging using MRI or PET scans at various points before and after treatment or enrollment. During the study, participants complete memory and thinking tests and undergo brain scans before treatment, immediately after chemotherapy, and six months later. Researchers measure changes in cognitive performance and brain markers like amyloid and tau accumulation. The study monitors participants for cognitive effects related to chemotherapy and continues until January 2028.
CONDITIONS
Brief Title
Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer
Research Team
M
Michael W Parsons, PhD
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