Actively Recruiting
Chemotherapy With Rituximab for Aggressive B-NHL in Children and Adolescents
Led by Children's Cancer Group, China · Updated on 2025-09-11
87
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
Sponsors
C
Children's Cancer Group, China
Lead Sponsor
S
Shanghai Children's Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to test whether intensive chemotherapy combined with early, adequate, and intensive use of Rituximab for aggressive B-NHL in children and adolescents can improve the EFS and OS compared with the historical study CCCG-BNHL-2015.
CONDITIONS
Official Title
Chemotherapy With Rituximab for Aggressive B-NHL in Children and Adolescents
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histology or cytologically confirmed mature B-cell NHL/AL (Burkitt, DLBCL, PMLBL, or aggressive mature B-cell NHL not otherwise specified)
- Ability to comply with scheduled follow-up and toxicity management
- Signed informed consent
You will not qualify if you...
- Follicular lymphoma, MALT, and nodular marginal zone lymphoma
- Congenital immunodeficiency, chromosomal breakage syndrome, prior organ transplantation
- Previous malignancy of any type or known positive HIV serology
- Pregnancy or lactation
- Past or current anti-cancer treatment except corticosteroids for less than one week
- Tumor cells negative for CD20
- Prior exposure to Rituximab
- Hepatitis B carrier status, history of HBV, or positive HBV serology
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shanghai Children's Medical Center
Shanghai, Shanghai Municipality, China, 201315
Actively Recruiting
Research Team
Y
Yi-jin Gao
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
4
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