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ID06427538

Study of Regular Saline Flushing of Chest Drains in Patients with Complicated Parapneumonic Effusions and Empyemas to Improve Drainage and Recovery

Led by Vanderbilt University Medical Center · Updated on 2026-02-20

96

Participants Needed

5

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

This research aims to evaluate the effect of regularly flushing chest drains in patients with complicated parapneumonic pleural effusions and empyemas, which are infections in the pleural space requiring antibiotics and chest tube drainage. The study focuses on whether flushing the chest drain with saline solution can help prevent blockages, improve drainage, and potentially reduce the length of hospital stay and need for additional interventions. This is a randomized trial addressing a practice that has not been studied in controlled trials before. Participants will be randomly assigned to one of two groups one group will receive routine flushing of their chest tube with 20 mL of sterile saline every 6 hours, administered by study team members, considering certain therapies as flushes the other group will receive saline flushes only if needed to unblock the tube, with no routine flushing. The study follows British Thoracic Society guidelines recommending flushing for small chest drains, but the overall value of this practice is being assessed. During the study, patients will be monitored for the time it takes until chest tube removal, length of hospital stay, chest x-ray improvements, the need for further surgical procedures, and any complications. These assessments will continue up to three months, with chest imaging compared at placement and removal. The study involves inpatient management and ongoing safety evaluations to understand the impact of flushing on patient outcomes.

CONDITIONS

Brief Title

Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas

Research Team

S

Samira Shojaee, MD, MPH

J

Jennifer Duke, MD

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