Actively Recruiting
Comparative Outcomes of Chest Wall Reconstruction Using Twisted Steel Wires Versus Bone Cement: A Cohort Study
Led by University of Health Sciences Lahore · Updated on 2026-01-13
50
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating two methods of chest wall reconstruction in patients who have undergone chest wall resection due to tumors, infections, or trauma. The study compares the use of twisted stainless steel wires versus polymethyl methacrylate (PMMA) bone cement to assess postoperative outcomes, complications, and cost-effectiveness. This research is conducted in a high-volume thoracic surgery center in Lahore, aiming to find an optimal reconstructive strategy suitable for resource-limited settings. Two groups are compared: one receiving chest wall reconstruction with twisted stainless steel wires that provide flexible, dynamic support, and another with PMMA bone cement forming a rigid prosthesis fixed to adjacent ribs. The wire technique allows chest wall movement and is a low-cost alternative, while the bone cement method is more rigid and costly. The study period spans from January 2025 to December 2026, observing patients after surgery. Participants undergo assessments for postoperative pain at 24 hours, 48 hours, and 7 days, as well as evaluations of chest wall movement at 1 and 3 months after surgery. Researchers also monitor respiratory function, chest wall stability, complications such as infection or wound issues, hospital stay length, readmission rates, and overall reconstruction costs. This comprehensive follow-up helps compare clinical and functional outcomes between the two reconstruction methods over time.
CONDITIONS
Brief Title
Chest Wall Reconstruction Cohort
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years or older undergoing partial or full-thickness chest wall resection
- Chest wall defects requiring rigid or semi-rigid reconstruction involving two or more ribs or the sternum
You will not qualify if you...
- Patients with small chest wall defects managed by primary closure or soft tissue-only reconstruction
- Patients undergoing major intrathoracic resections such as pneumonectomy that may affect respiratory assessment
- Patients with recurrent disease requiring revision reconstruction
- Patients unwilling or unable to provide consent or comply with follow-up visits
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery day and hospital stay immediately after
Participants undergo chest wall reconstruction surgery using either twisted stainless steel wires or PMMA bone cement to restore chest wall stability and function.
Surgery visit and daily post-operative assessments during hospital stay
Duration - Up to 3 months post-surgery
Participants are assessed for postoperative pain, chest wall movement, and respiratory function to evaluate recovery and outcomes of the reconstruction.
Visits at 24 hours, 48 hours, 7 days, 1 month, and 3 months post-operatively
Trial Site Locations
Total: 1 location
1
Services Hospital, Lahore
Lahore, Punjab Province, Pakistan, 54000
Actively Recruiting
Research Team
M
Muhammad Shoaib Nabi, FCPS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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