Actively Recruiting

All Genders
Healthy Volunteers
NCT01120353

Childhood Cancer Survivor Study

Led by St. Jude Children's Research Hospital · Updated on 2026-04-24

50000

Participants Needed

31

Research Sites

1660 weeks

Total Duration

On this page

Sponsors

S

St. Jude Children's Research Hospital

Lead Sponsor

N

National Cancer Institute (NCI)

Collaborating Sponsor

AI-Summary

What this Trial Is About

The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.

CONDITIONS

Official Title

Childhood Cancer Survivor Study

Who Can Participate

All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Survived at least 5 years after diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 between 1970 and 1986 at a participating center
  • Survived at least 5 years after diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 between 1987 and 1999 at a participating center
  • English- or Spanish-speaking
  • Living in the United States or Canada at the time of diagnosis
Not Eligible

You will not qualify if you...

  • Diagnosis of non-malignant tumors such as Langerhans cell histiocytosis, meningioma, or craniopharyngioma treated with radiation and/or chemotherapy
  • Non-English speaking
  • Living outside the United States or Canada

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 31 locations

1

University of Alabama at Birmingham/Children's of Alabama

Birmingham, Alabama, United States, 35294

Actively Recruiting

2

City of Hope National Medical Center

Duarte, California, United States, 91010

Actively Recruiting

3

Children's Hospital Los Angeles

Los Angeles, California, United States, 90027

Actively Recruiting

4

University of California-Los Angeles

Los Angeles, California, United States, 90095

Actively Recruiting

5

Children's Hospital of Orange County

Orange, California, United States, 92868

Actively Recruiting

6

University of California-San Francisco

San Francisco, California, United States, 94143

Actively Recruiting

7

Stanford University School of Medicine

Stanford, California, United States, 94305

Actively Recruiting

8

Children's Hospital Colorado

Aurora, Colorado, United States, 80045

Actively Recruiting

9

Children's National Medical Center

Washington D.C., District of Columbia, United States, 20010

Actively Recruiting

10

Emory University/Children's Health Care of Atlanta

Atlanta, Georgia, United States, 30322

Actively Recruiting

11

Ana & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, United States, 60611-2605

Actively Recruiting

12

University of Chicago

Chicago, Illinois, United States, 60637

Actively Recruiting

13

Indiana University/Riley Hospital for Children

Indianapolis, Indiana, United States, 46202

Actively Recruiting

14

Dana-Farber Cancer Institute

Boston, Massachusetts, United States, 02215

Actively Recruiting

15

University of Michigan/Mott Children's Hospital

Ann Arbor, Michigan, United States, 48109

Actively Recruiting

16

Children's Hospitals & Clinics of Minnesota

Minneapolis, Minnesota, United States, 55404

Actively Recruiting

17

University of Minnesota

Minneapolis, Minnesota, United States, 55455

Completed

18

Mayo Clinic

Rochester, Minnesota, United States, 55905

Completed

19

St. Louis Children's Hospital/The Washington University

St Louis, Missouri, United States, 63130

Actively Recruiting

20

Roswell Park Cancer Institute

Buffalo, New York, United States, 14263

Actively Recruiting

21

Memorial-Sloan Kettering Cancer Center

New York, New York, United States, 10065

Actively Recruiting

22

Nationwide Children's Hospital

Columbus, Ohio, United States, 43205

Actively Recruiting

23

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States, 19104

Actively Recruiting

24

Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, United States, 15213

Actively Recruiting

25

St. Jude Children's Research Hospital

Memphis, Tennessee, United States, 38105

Actively Recruiting

26

University of Texas Southwestern Medical Center

Dallas, Texas, United States, 75390

Completed

27

Cook Children's Medical Center

Fort Worth, Texas, United States, 76104

Actively Recruiting

28

M.D. Anderson Cancer Center

Houston, Texas, United States, 77030

Actively Recruiting

29

Texas Children's Hospital

Houston, Texas, United States, 77030

Actively Recruiting

30

Seattle Children's Hospital

Seattle, Washington, United States, 98105

Actively Recruiting

31

The Hospital for Sick Children

Toronto, Ontario, Canada, M5G-1XB

Actively Recruiting

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Research Team

G

Gregory T. Armstrong, MD, MSCE

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Childhood Cancer Survivor Study | DecenTrialz