Actively Recruiting
Childhood-Onset Essential Hypertension Natural History Study
Led by National Human Genome Research Institute (NHGRI) · Updated on 2025-12-02
2300
Participants Needed
1
Research Sites
497 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Childhood-onset essential hypertension (COEH) is high blood pressure that develops in children and teens. High blood pressure is a major risk factor for heart disease. COEH is more likely to be caused by changes in genes rather than by factors like stress or diet. Researchers want to learn more about how changes in genes relate to COEH. They hope to use that information to develop better treatments for children with high blood pressure. Objective: This natural history study will look for genes and gene changes that may lead to COEH. Eligibility: People aged 2 years and older with COEH or who had COEH when they were children. Healthy relatives of those with COEH are also needed. Design: Participants will have one clinic visit per year for up to 10 years. All participants will have a physical exam. They will provide samples of blood and urine. At their first visit, they will have a swab (like a Q-tip) rubbed between their gums and cheeks. They may agree to having a skin biopsy; a piece of skin about the size of a pencil eraser will be removed. Affected participants aged 2 to 17 years old will have additional tests: * They will have sensors placed on their skin to look at their blood vessels and see how blood is moving in their bodies. * They will lie or stand while a machine measures the amount of fat and muscle in their bodies. * They will have an ultrasound; a wand will be rubbed against their skin to take pictures of their kidneys. Other things are optional for all participants: * They may have photographs taken of their bodies. * They may have tests of their heart function. * They may have different types of imaging scans.
CONDITIONS
Official Title
Childhood-Onset Essential Hypertension Natural History Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 2 to 12 years with blood pressure above the 95th percentile or 120/80 mm Hg, willing to provide samples and undergo exams and imaging
- Age 13 to 17 years with blood pressure at least 130/80 mm Hg, willing to provide samples and undergo exams and imaging
- Age 18 years or older with a history of childhood-onset essential hypertension meeting above criteria, willing to provide samples and undergo exams
- First-degree relatives of affected individuals, willing to provide samples and undergo exams
- Individuals with a candidate genetic variant identified by prior testing, willing to provide medical information, undergo exams, and imaging if aged 2 to 17 with COEH evidence
You will not qualify if you...
- Body mass index (BMI) above the 95th percentile
- Hypertension caused by a known secondary condition such as chronic kidney disease, aortopathy, or sleep apnea
- Impaired decision-making ability, with or without a legally authorized representative
- For unaffected individuals: prior or current diagnosis of childhood-onset essential hypertension
- For unaffected individuals: second-degree or more distant relationship to affected family member
- For individuals with candidate genetic variants: no prior genetic test results available for confirmation
- Impaired decision-making ability, with or without a legally authorized representative
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
E
Emilyn C Banfield
CONTACT
N
Neil A Hanchard, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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