Actively Recruiting

Age: 8Years - 100Years
All Genders
Healthy Volunteers
ID02390765

Children's Growth and Behavior Study Understanding Eating Behavior and Health in Youth Longitudinal Observational Study

Led by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Updated on 2026-06-08

1500

Participants Needed

1

Research Sites

2 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying how genes and the environment influence children's eating behavior and health over time, focusing on youth aged 8 to 17 years. This observational study aims to understand the patterns of eating behavior that may lead to excessive weight gain and related health problems. The study will follow healthy obese and non-obese boys and girls for up to six years to identify early risk factors and mechanisms influencing eating habits and weight changes. Participants will undergo extensive evaluations including medical history, physical exams, body measurements, and cognitive and behavioral tests. The study involves wearing wrist monitors for two weeks to track sleep and mood, answering smartphone prompts about eating, and providing biological samples such as stool, saliva, urine, and blood. Annual visits include repeated body measurements, X-rays, questionnaires, and thinking and behavior assessments. Additional optional studies include stress and hormone testing, brain imaging, and sleep/fatigue experiments. During participation, children and their parents will attend screening visits and up to six yearly follow-ups lasting 3 to 8 hours each. Assessments include heart tests, laboratory meals, interviews, and computerized tasks to evaluate mood, cognition, and eating behavior. Parents may also provide medical information and samples. The primary outcome measured is differences in children's eating behavior over six years. Participants will be compensated for their time and involvement throughout the study.

CONDITIONS

Brief Title

Children s Growth and Behavior Study

Who Can Participate

Age: 8Years - 100Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Children aged 8 to 17 years
  • Weight, height, and BMI at or above the 5th percentile for age and sex
  • Cognitively able to complete study procedures (FSIQ 70 or higher)
  • Good general health with no serious illnesses apart from overweight or minor, well-controlled conditions
  • Parents or guardians aged 18 years or older with a child enrolled in the study
Not Eligible

You will not qualify if you...

  • History of major cardiovascular disease or serious obesity-related complications
  • Untreated or major endocrine or cardiovascular illnesses
  • Major renal, hepatic, gastrointestinal, hematological, or pulmonary disorders (except asthma not needing continuous medication)
  • Regular use of medications known to affect body weight or eating behavior
  • Current pregnancy or history of pregnancy; postmenarcheal girls must have a negative pregnancy test
  • Regular use of tobacco or alcohol
  • Significant weight loss over 5% in the past three months
  • History of significant brain injury affecting cognitive performance
  • Presence of major psychiatric disorders such as schizophrenia, bipolar disorder, or eating disorders
  • Any condition that would hinder study compliance or completion
  • Additional exclusions for stool sample collection, including certain intestinal disorders, recent diarrhea, or recent antibiotic use
  • Specific exclusions for experimental sub-studies, including medication use affecting autonomic/endocrine function, high physical activity, MRI contraindications, and left-handedness for brain imaging studies

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

2 visits for eligibility and baseline evaluations

Diagnostic Evaluation

Duration - Approximately 2 weeks

Participants complete extensive baseline evaluations including psychological, neurocognitive, and behavioral assessments, as well as monitoring sleep and eating behaviors.

2 visits plus 2 weeks of sleep and behavior monitoring using wrist actigraphy and smartphones

Long-term Monitoring

Duration - Up to 6 years

Participants complete annual evaluations of weight and adiposity for up to six years, with more extensive assessments of self-regulatory, motivational, and neurocognitive functions every three years.

Annual visits with more extensive evaluations every three years

Trial Site Locations

Total: 1 location

1

National Institutes of Health Clinical Center

Bethesda, Maryland, United States, 20892

Actively Recruiting

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Research Team

B

Bobby K Cheon

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Published Research Related To This Trial

Eating-disordered behaviors, body fat, and psychopathology in overweight and normal-weight children.

Marian Tanofsky-Kraff, Susan Z Yanovski, Denise E Wilfley...

https://pubmed.ncbi.nlm.nih.gov/14756614

A prospective study of psychological predictors of body fat gain among children at high risk for adult obesity.

Marian Tanofsky-Kraff, Marc L Cohen, Susan Z Yanovski...

https://pubmed.ncbi.nlm.nih.gov/16585316

The Effect of Experimentally Induced Cognitive Fatigue on Energy Intake Among Youth With and Without Recent Reported Dietary Restraint.

Megan N Parker, Marian Tanofsky-Kraff, Bess F Bloomer...

https://pubmed.ncbi.nlm.nih.gov/40878932

Cognitive fatigue did not significantly influence youth's total energy intake or snack food consumption during a randomized trial.

Megan N Parker, Nichole R Kelly, Alexa Moore...

https://pubmed.ncbi.nlm.nih.gov/40489009

Independent and Interactive Associations of Subjective and Objective Socioeconomic Status With Body Composition and Parent-Reported Hyperphagia Among Children.

Meegan R Smith, Julia M P Bittner, Lucy K Loch...

https://pubmed.ncbi.nlm.nih.gov/37943608