Actively Recruiting

Age: 12Years +
All Genders
ID05334927

China HeadAche DIsorders RegiStry

Led by Beijing Tiantan Hospital · Updated on 2026-01-15

10000

Participants Needed

20

Research Sites

52 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying patients aged 12 years and older who have primary headaches or medication-overuse headache (MOH). The study collects detailed information including biomarkers, imaging features, cognition tests, genetic data, social and demographic factors, medical history, treatments used, and outcomes related to headache disorders. This large registry plans long-term follow-up to better understand headache-related diseases and their progression. The study includes several groups based on headache type: medication overuse headache or new daily persistent headache, chronic migraine, episodic migraine, and other primary headaches. Some participants receive treatments prescribed in routine clinical practice, such as Yangxue Qingnao Granules or biological drugs like eptinezumab and erenumab, with treatment details decided by their doctors and patients. Follow-up visits occur frequently in the first 18 to 24 months and then annually thereafter. Participants will be followed up regularly at specific time points including 1, 2, 3, 6, 9, 12, 18, and 24 months, then annually for up to 10 years. Researchers will perform assessments such as MRI scans, cognitive tests like MoCA and MMSE, headache diaries, and various questionnaires on disability, anxiety, depression, sleep quality, and fatigue. Long-term monitoring aims to capture headache days, genetic analysis, brain imaging changes, and quality of life outcomes over a decade.

CONDITIONS

Brief Title

China HeadAche DIsorders RegiStry

Who Can Participate

Age: 12Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 12 years or older, any gender
  • First onset of primary headache before age 50 (under 65 for chronic migraine)
  • Diagnosed with primary headache or primary headache with medication overuse headache according to ICHD-3
  • Signed informed consent form
Not Eligible

You will not qualify if you...

  • Headaches currently caused by secondary factors other than drug overuse
  • Cannot be diagnosed with primary headache or primary headache with medication overuse headache according to ICHD-3
  • Severe mental illnesses such as schizophrenia or mental retardation-related disorders
  • Severe organic diseases like malignant tumors with expected survival less than 1 year
  • Pregnant, planning pregnancy, or breastfeeding
  • Participating in other clinical trials
  • Unable to complete follow-up due to geographic or other reasons

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Behavioral Observation and Follow-up

Duration - Up to 10 years

Participants with different types of primary headache are followed up according to their headache subtype. For Medicine Overuse Headache and New Daily Persistent Headache, participants have monthly visits for the first 18 months, a visit at 24 months, then annual visits thereafter. For Chronic Migraine and Episodic Migraine, participants have visits at 1, 2, 3, 6, 9, 12, 18, and 24 months, then annual visits. For other primary headaches, participants have visits at 3, 6, and 9 months.

Monthly visits for 18 months, then visits at 24 months and annually thereafter depending on headache type

Drug Observation Period

Duration - 12 weeks

Participants prescribed Yangxue Qingnao Granules/Pills in routine clinical practice are observed over a 12-week period. Treatment initiation, dosing, frequency, and duration are determined by the treating physician and patient. Participants are followed with outcome assessments including relief of headache episodes and symptom measures at weeks 4, 8, and 12.

Visits at baseline, and weeks 4, 8, and 12

Biological Treatment Observation

Duration - 12 weeks with possible additional follow-up

Participants receiving eptinezumab or erenumab for migraine prophylaxis in routine clinical practice are observed. Treatment decisions are made by the treating physician and patient. Outcome assessments are captured approximately every 4 weeks during a 12-week observation window, with additional follow-up when available.

Visits approximately every 4 weeks during 12 weeks

Trial Site Locations

Total: 20 locations

1

Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, China, 100070

Actively Recruiting

2

Beijing Chaoyang Hospital

Beijing, Beijing Municipality, China

Actively Recruiting

3

Chongqing People's Hospital

Chongqing, Chongqing Municipality, China

Actively Recruiting

4

Fujian Provincial Hospital

Fuzhou, Fujian, China

Actively Recruiting

5

The First Affiliated Hospital of Guangxi University of Chinese Medicine

Nanning, Guangxi, China

Actively Recruiting

6

The First People's Hospital of Zunyi

Zunyi, Guizhou, China

Actively Recruiting

7

Ruijin-Hainan Hospital Shanghai Jiao Tong University School Of Medicine

Qionghai, Hainan, China

Actively Recruiting

8

Zhangjiakou First Hospital

Zhangjiakou, Hebei, China

Actively Recruiting

9

Luohe Central Hospital

Luohe, Henan, China

Actively Recruiting

10

Luoyang Central Hospital

Luoyang, Henan, China

Actively Recruiting

11

The Second Affiliated Hospital of Henan University of Science and Technology

Luoyang, Henan, China

Actively Recruiting

12

The 7th People's Hospital of Zhengzhou

Zhengzhou, Henan, China

Actively Recruiting

13

Changzhou First People's Hospital

Changzhou, Jiangsu, China

Actively Recruiting

14

Jiujiang First People's Hospital

Jiujiang, Jiangxi, China

Actively Recruiting

15

The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China

Actively Recruiting

16

Huludao Central Hospital

Huludao, Liaoning, China

Actively Recruiting

17

Zibo Municipal Hospital

Zibo, Shandong, China

Actively Recruiting

18

Dachuan District People's Hospital

Dazhou, Sichuan, China

Actively Recruiting

19

Deyang People's Hospital

Deyang, Sichuan, China

Actively Recruiting

20

The First People's Hospital of Guangyuan

Guangyuan, Sichuan, China

Actively Recruiting

Loading map...

Research Team

Y

Yong Gang Wang, Doctor

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

4

Similar Trials

A Comparison of Biodegradable and Metal Occluders in Patient...

PFO - Patent Foramen Ovale

Actively Recruiting

2 locations

Frequently Asked Questions

Have more questions? Get in touch with our team for quick support

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

Published Research Related To This Trial

Abnormal neurovascular coupling in the precuneus associated with migraine chronification: A multimodal magnetic resonance imaging study.

Cunxin Lin, Yuanxiang Li, Zhuang Wang...

https://pubmed.ncbi.nlm.nih.gov/41223010

Altered functional connectivity of brainstem nuclei in new daily persistent headache: Evidence from resting-state functional magnetic resonance imaging.

Wei Wang, Dong Qiu, Yanliang Mei...

https://pubmed.ncbi.nlm.nih.gov/38516817

Mapping the aberrant brain functional connectivity in new daily persistent headache: a resting-state functional magnetic resonance imaging study.

Wei Wang, Ziyu Yuan, Xueyan Zhang...

https://pubmed.ncbi.nlm.nih.gov/37098469