Abnormal neurovascular coupling in the precuneus associated with migraine chronification: A multimodal magnetic resonance imaging study.
Cunxin Lin, Yuanxiang Li, Zhuang Wang...
https://pubmed.ncbi.nlm.nih.gov/41223010Actively Recruiting
Led by Beijing Tiantan Hospital · Updated on 2026-01-15
10000
Participants Needed
20
Research Sites
52 weeks
Total Duration
Researchers are studying patients aged 12 years and older who have primary headaches or medication-overuse headache (MOH). The study collects detailed information including biomarkers, imaging features, cognition tests, genetic data, social and demographic factors, medical history, treatments used, and outcomes related to headache disorders. This large registry plans long-term follow-up to better understand headache-related diseases and their progression. The study includes several groups based on headache type: medication overuse headache or new daily persistent headache, chronic migraine, episodic migraine, and other primary headaches. Some participants receive treatments prescribed in routine clinical practice, such as Yangxue Qingnao Granules or biological drugs like eptinezumab and erenumab, with treatment details decided by their doctors and patients. Follow-up visits occur frequently in the first 18 to 24 months and then annually thereafter. Participants will be followed up regularly at specific time points including 1, 2, 3, 6, 9, 12, 18, and 24 months, then annually for up to 10 years. Researchers will perform assessments such as MRI scans, cognitive tests like MoCA and MMSE, headache diaries, and various questionnaires on disability, anxiety, depression, sleep quality, and fatigue. Long-term monitoring aims to capture headache days, genetic analysis, brain imaging changes, and quality of life outcomes over a decade.
CONDITIONS
China HeadAche DIsorders RegiStry
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 10 years
Participants with different types of primary headache are followed up according to their headache subtype. For Medicine Overuse Headache and New Daily Persistent Headache, participants have monthly visits for the first 18 months, a visit at 24 months, then annual visits thereafter. For Chronic Migraine and Episodic Migraine, participants have visits at 1, 2, 3, 6, 9, 12, 18, and 24 months, then annual visits. For other primary headaches, participants have visits at 3, 6, and 9 months.
Monthly visits for 18 months, then visits at 24 months and annually thereafter depending on headache type
Duration - 12 weeks
Participants prescribed Yangxue Qingnao Granules/Pills in routine clinical practice are observed over a 12-week period. Treatment initiation, dosing, frequency, and duration are determined by the treating physician and patient. Participants are followed with outcome assessments including relief of headache episodes and symptom measures at weeks 4, 8, and 12.
Visits at baseline, and weeks 4, 8, and 12
Duration - 12 weeks with possible additional follow-up
Participants receiving eptinezumab or erenumab for migraine prophylaxis in routine clinical practice are observed. Treatment decisions are made by the treating physician and patient. Outcome assessments are captured approximately every 4 weeks during a 12-week observation window, with additional follow-up when available.
Visits approximately every 4 weeks during 12 weeks
Total: 20 locations
1
Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100070
Actively Recruiting
2
Beijing Chaoyang Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
3
Chongqing People's Hospital
Chongqing, Chongqing Municipality, China
Actively Recruiting
4
Fujian Provincial Hospital
Fuzhou, Fujian, China
Actively Recruiting
5
The First Affiliated Hospital of Guangxi University of Chinese Medicine
Nanning, Guangxi, China
Actively Recruiting
6
The First People's Hospital of Zunyi
Zunyi, Guizhou, China
Actively Recruiting
7
Ruijin-Hainan Hospital Shanghai Jiao Tong University School Of Medicine
Qionghai, Hainan, China
Actively Recruiting
8
Zhangjiakou First Hospital
Zhangjiakou, Hebei, China
Actively Recruiting
9
Luohe Central Hospital
Luohe, Henan, China
Actively Recruiting
10
Luoyang Central Hospital
Luoyang, Henan, China
Actively Recruiting
11
The Second Affiliated Hospital of Henan University of Science and Technology
Luoyang, Henan, China
Actively Recruiting
12
The 7th People's Hospital of Zhengzhou
Zhengzhou, Henan, China
Actively Recruiting
13
Changzhou First People's Hospital
Changzhou, Jiangsu, China
Actively Recruiting
14
Jiujiang First People's Hospital
Jiujiang, Jiangxi, China
Actively Recruiting
15
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
Actively Recruiting
16
Huludao Central Hospital
Huludao, Liaoning, China
Actively Recruiting
17
Zibo Municipal Hospital
Zibo, Shandong, China
Actively Recruiting
18
Dachuan District People's Hospital
Dazhou, Sichuan, China
Actively Recruiting
19
Deyang People's Hospital
Deyang, Sichuan, China
Actively Recruiting
20
The First People's Hospital of Guangyuan
Guangyuan, Sichuan, China
Actively Recruiting
Y
Yong Gang Wang, Doctor
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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